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Assessment of glycohemoglobin, plasma glucose curve and C-reactive protein as complementary predictors to diagnose prediabetes: a transversal study


The shape of the plasma glucose curve has been considered as a predictor for diabetes in the future, and it could be used to diagnose prediabetes.


This study aims to assess the relationship between glycohemoglobin, C-reactive protein (CRP), oxidative stress markers levels and the shape of the plasma glucose curve during the oral glucose tolerance test (OGTT).

Material and methods

A transversal study was carried out with 59 non-diabetic subjects with increased diabetes risk who underwent an OGTT to analyze glycemia, insulin, glycohemoglobin, lipids, C-reactive protein, malondialdehyde and carbonyl protein. Glycemia was assessed at fasting, 30, 60 and 120 min.


Overall, 26 individuals had prediabetes, 28 did not have prediabetes (22 had 1h-OGTT>fasting glycemia, 6 had 1h-OGTT≤fasting glycemia) and 5 had diabetes. The 1h-OGTT≤fasting glycemia and diabetes groups were excluded, and then a non-parametric test (Mann-Whitney U test) was used to analyze data. There were no statistical differences between 1h-OGTT>fasting glycemia and prediabetes groups in the analysis of glycohemoglobin [5.15 (4.8-5.4); 5.20 (5.10-5.4); p=0.17 ], C-reactive protein [3.70 (1.8-8.9); 3.96 (1.45-7.13); p=0.38], lipids and malondialdehyde, but there were differences in fasting, 30, 60 and 120 min glycemia, insulin level [11(8-13); 13(10-18); p=0.04], Homeostatic Model Assessment-IR [2.45(1.93-2.95); 3.30(2.51-5.02); p=0.00] and carbonyl protein [0.48 (0.42-0.58); 0.57 (0.5-0.76); p=0.02].


These results identify predictors to increased cardiovascular and diabetes risk in individuals without prediabetes and with 1h-OGTT>fasting glycemia, which are similar to predictors in individuals with prediabetes established by the American Diabetes Association criteria.

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Corresponding author

Correspondence to Marcelo da Silva Biavaschi.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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da Silva Biavaschi, M., Schmatz, R., Gutierres, J.M. et al. Assessment of glycohemoglobin, plasma glucose curve and C-reactive protein as complementary predictors to diagnose prediabetes: a transversal study. Diabetol Metab Syndr 7, A153 (2015).

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  • Lipid
  • Oral Glucose Tolerance Test
  • Diabetes Group
  • American Diabetes Association
  • Carbonyl Protein