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Insulin secretion pattern in patients with congenital adrenal hyperplasia during the hyperglycemic clamp compared with a control group


Intrauterine hypocortisolism and postnatal corticosteroids chronic replacement, which does not mimic the physiological pattern, are characteristic of patients with the classic form of congenital adrenal hyperplasia (CAH) by deficiency of the 21-hydroxylase enzyme (21OHD). Long-term effects studies of this treatment on insulin secretion pattern by pancreatic beta cells are scarce.


Evaluate the function of pancreatic β cells and peripheral insulin resistance through the hyperglycemic clamp in patients with the classic form of CAH-21OHD and compare with healthy individuals.

Materials and methods

The hyperglycemic clamp was applied, the gold standard method for evaluating secretory function of pancreatic beta cells.


The patients with CAH-21OHD, showed an increase of insulin resistance and compensatory insulin secretion resulting in normal glucose homeostasis.


Young adult patients with CAH-21OHD have a normal glucose metabolism by functional adaptation of hypersecretory beta cell. Strategies for the maintenance of the physiological adaptive pattern should be developed to ensure long-term normoglycemia in this specific population.

Author information

Correspondence to Daniel Minutti de Oliveira.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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  • Insulin Resistance
  • Beta Cell
  • Congenital Adrenal Hyperplasia
  • Normal Glucose
  • Classic Form