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Table 1 Serum parameters in mice

From: Liraglutide counteracts obesity and glucose intolerance in a mouse model of glucocorticoid-induced metabolic syndrome

 

Experimental groups

Vehicle/PBS

GC/PBS

Vehicle/Lira

GC/Lira

Corticosterone (ng/ml)

6.72 ± 2.29

46.56 ± 4.78*

7.83 ± 2.18

65.29 ± 10.6*

Corticotropin (pg/ml)

122 ± 14

45 ± 8*

134 ± 18

39 ± 14*

NEFA (mmol/L)

0.86 ± 0.04

1.30 ± 0.11*

0.92 ± 0.07

1.22 ± 0.14

Cholesterol (mmol/L)

2.84 ± 0.19

5.29 ± 0.46*

2.61 ± 0.12

4.16 ± 0.68*

Triglycerides (mmol/L)

1.26 ± 0.06

4.13 ± 1.10*

1.39 ± 0.15

2.98 ± 0.75

  1. Male C57Bl/6J mice were treated with 1% ethanol (vehicle) or 100 μg/ml corticosterone (GC) via their drinking water together with once-daily injections of either PBS or liraglutide (Lira) at a final dose of 0.3 mg per kg body weight for five consecutive weeks (n = 5-6). At the end of the study, blood was collected by heart puncture and serum was obtained. Serum levels for the indicated parameters are shown as mean ± s.e.m. A * denotes a significant (p < 0.05) effect of corticosterone treatment.