| Experimental groups |
---|
Vehicle/PBS | GC/PBS | Vehicle/Lira | GC/Lira |
---|
Corticosterone (ng/ml) | 6.72 ± 2.29 | 46.56 ± 4.78* | 7.83 ± 2.18 | 65.29 ± 10.6* |
Corticotropin (pg/ml) | 122 ± 14 | 45 ± 8* | 134 ± 18 | 39 ± 14* |
NEFA (mmol/L) | 0.86 ± 0.04 | 1.30 ± 0.11* | 0.92 ± 0.07 | 1.22 ± 0.14 |
Cholesterol (mmol/L) | 2.84 ± 0.19 | 5.29 ± 0.46* | 2.61 ± 0.12 | 4.16 ± 0.68* |
Triglycerides (mmol/L) | 1.26 ± 0.06 | 4.13 ± 1.10* | 1.39 ± 0.15 | 2.98 ± 0.75 |
- Male C57Bl/6J mice were treated with 1% ethanol (vehicle) or 100 μg/ml corticosterone (GC) via their drinking water together with once-daily injections of either PBS or liraglutide (Lira) at a final dose of 0.3 mg per kg body weight for five consecutive weeks (n = 5-6). At the end of the study, blood was collected by heart puncture and serum was obtained. Serum levels for the indicated parameters are shown as mean ± s.e.m. A * denotes a significant (p < 0.05) effect of corticosterone treatment.