Skip to main content

Advertisement

Table 4 SNPs significantly associated with MetS score

From: Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal

Gene Genotype n MetS score Mean difference 95%CI P-value a Corrected P-valueb
CYP2C19 GG 156 0.192 ± 1.380 0.792 0.351-1.233 0.00049 0.018
rs4244285 GA + AA1 50 -0.600 ± 1.362     
GABRA2 AA 63 0.350 ± 1.374 0.504 0.087-0.921 0.018 0.670
rs279871 GA + GG2 143 -0.154 ± 1.409     
NPY AA 58 0.342 ± 1.606 0.476 0.048-0.904 0.029 0.999
rs16147 GA + GG3 148 -0.134 ± 1.313     
TPMT AA 192 -0.080 ± 1.375 1.199 0.413-1.984 0.003 0.109
rs1142345 GA 13 1.119 ± 1.601     
  1. aT-test was used to compare MetS score mean values between the two groups.
  2. bCorrected P-values were obtained using the Bonferroni test to multiple testing correction.
  3. 1The GA + AA group consists on 3 AA and 47 GA individuals.
  4. 2The GA + GG group consists on 36 AA and 107 GA individuals.
  5. 3The GA + GG group consists on 37 AA and 111 GA individuals.
  6. The MetS score is presented as mean ± SD.