Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal

Table 4 SNPs significantly associated with MetS score

Gene	Genotype	n	MetS score	Mean difference	95%CI	P-value ^a	Corrected P-value^b
*CYP2C19*	GG	156	0.192 ± 1.380	0.792	0.351-1.233	0.00049	0.018
rs4244285	GA + AA¹	50	-0.600 ± 1.362
*GABRA2*	AA	63	0.350 ± 1.374	0.504	0.087-0.921	0.018	0.670
rs279871	GA + GG²	143	-0.154 ± 1.409
*NPY*	AA	58	0.342 ± 1.606	0.476	0.048-0.904	0.029	0.999
rs16147	GA + GG³	148	-0.134 ± 1.313
*TPMT*	AA	192	-0.080 ± 1.375	1.199	0.413-1.984	0.003	0.109
rs1142345	GA	13	1.119 ± 1.601

^aT-test was used to compare MetS score mean values between the two groups.
^bCorrected P-values were obtained using the Bonferroni test to multiple testing correction.
¹The GA + AA group consists on 3 AA and 47 GA individuals.
²The GA + GG group consists on 36 AA and 107 GA individuals.
³The GA + GG group consists on 37 AA and 111 GA individuals.
The MetS score is presented as mean ± SD.

ISSN: 1758-5996