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Table 1 Baseline clinical characteristics of subjects with NGT and T2DM

From: Circulating levels of irisin in middle-aged first-degree relatives of type 2 diabetes mellitus — correlation with pancreatic β-cell function

  NGT T2DM P value
n 62 60  
Age (years) 52.03±5.59 51.81±5.77 0.837
Sex (M/F) 28/34 29/31 0.446
Waist (cm) 80.55±9.06 87.41±8.55 <0.001
Hip (cm) 91.40±5.58 93.26±6.87 0.106
WHR 0.88±0.08 0.94±0.08 <0.001
BMI (kg/m2) 24.07±3.21 25.80±2.99 0.003
Systolic BP (mmHg) 121.53±13.97 134.17±16.14 <0.001
Diastolic BP (mmHg) 78.68±9.00 84.66±10.12 0.001
TC (mM) 5.27±1.26 5.43±1.09 0.47
TG (mM) 1.25±0.66 2.27±1.77 <0.001
HDL-C (mM) 1.31±0.29 1.32±0.24 0.901
LDL -C(mM) 3.11±0.88 3.14±0.80 0.837
FFA (mM) 0.35±0.14 0.59±0.24 <0.001
FPG (mM) 5.13±0.47 7.80±2.50 <0.001
2h PG (mM) 5.84±1.10 15.61±4.34 <0.001
HbA1C (%) 5.50±0.34 7.00±1.78 <0.001
Insulin (mU) 6.42±3.62 9.68±4.17 <0.001
HOMA-β 82.63±47.49 61.25±43.16 0.011
HOMA-IR 1.48±0.90 3.20±1.33 <0.001
ALT (IU/L) 25.03±10.88 36.27±24.28 0.002
AST (IU/L) 22.73±5.34 27.23±14.41 0.026
Urea (mM) 4.67±1.21 4.76±0.98 0.674
Creatinine (μM) 62.26±14.04 58.17±13.87 0.108
Uric acid (μM) 258.81±76.83 301.57±76.99 0.003
eGFR (ml/min/1.73 m2) 104.73±21.13 117.40±31.12 0.011
Muscle mass (kg) 23.42±5.08 24.38±4.59 0.286
Fat mass (kg) 19.29±6.01 22.43±5.41 0.004
Percentage of body fat (%) 30.92±6.88 33.25±5.88 0.052
Irisin (ng/ml) 277.62±131.07 289.88 ±141.00 0.619
  1. Data are expressed as the mean ± SD.
  2. WHR: waist-to-hip ratio; BMI: body mass index; BP: blood pressure; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; FFA: free fatty acids; FPG: fasting plasma glucose; 2h PG: 2h plasma glucose; HbA1C: haemoglobin A1C; HOMA-β: homeostasis model assessment-β; HOMA-IR: homeostasis model assessment of insulin resistance; ALT: alanine transaminase; AST: aspartate transaminase; eGFR: estimated glomerular filtration rate.