From: Prediction of response to GLP-1 receptor agonist therapy in Japanese patients with type 2 diabetes
N | Median (Range) | Hazard ratio (95% CI) | P value | |
---|---|---|---|---|
BMI (kg/m2) | 43 | 26.31 (19.8-52.6) | ||
Tertile 1 (lowest) | 14 | 23.6 (19.8-25.0) | 1.0 (Reference) | |
Tertile 2 | 14 | 26.3 (25.1-30.3) | 3.9 (1.24-12.37) | 0.02 |
Tertile 3 (highest) | 15 | 33.2 (30.4-52.6) | 3.4 (1.04-11.01) | 0.04 |
Duration of diabetes (years) | 43 | 11 (0.1-38) | ||
Tertile 1 (lowest) | 15 | 4 (0.1-6) | 1.0 (Reference) | |
Tertile 2 | 15 | 12 (8-17) | 1.7 (0.67-4.4) | 0.25 |
Tertile 3 (highest) | 13 | 23 (18-38) | 1.7 (0.63-4.5) | 0.30 |
CPR6 (ng/mL) | 43 | 3.9 (0.5-11.0) | ||
Tertile 1 (lowest) | 15 | 2.0 (0.5-2.7) | 1.0 (Reference) | |
Tertile 2 | 14 | 4.0 (2.8-4.9) | 0.4 (0.13-1.01) | 0.054 |
Tertile 3 (highest) | 14 | 6.7 (5.3-11.0) | 1.3 (0.51-3.28) | 0.59 |
U-CPR (μg/day) | 43 | 71.6 (16.0-249.8) | ||
Tertile 1 (lowest) | 15 | 33.7 (16.0-49.7) | 1.0 (Reference) | |
Tertile 2 | 14 | 73.7 (50.8-112.8) | 0.4 (0.16-1.18) | 0.10 |
Tertile 3 (highest) | 14 | 160.0 (121.7-249.8) | 0.6 (0.23-1.34) | 0.19 |
Average preprandial glucose level over 2 days after the initiation of GLP-1 receptor agonist treatment (mg/dL) | 43 | 149.3 (99.8-246.2) | ||
Tertile 1 (lowest) | 15 | 130.3 (99.8-137.7) | 1.0 (Reference) | |
Tertile 2 | 14 | 149.7 (140.2-161.0) | 3.5 (1.19-10.12) | 0.02 |
Tertile 3 (highest) | 14 | 188.7 (161.5-246.2) | 3.1 (1.04-8.97) | 0.04 |
Previous antidiabetic treatment | 43 | |||
Diet and/or metformin | 11 | 1.0 (Reference) | ||
Sulfonylurea | 14 | 5.0 (1.13-22.16) | 0.03 | |
Insulin | 18 | 5.3 (1.16-24.56) | 0.03 |