Figure 1From: Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR ratsEffect of timed daily bromocriptine administration on ventromedial hypothalamic catecholamines. A. SHR rats exhibited elevated VMH NE release relative to Wistar normal controls (P < 0.0001). Timed daily bromocriptine administration significantly reduced VMH MHPG of SHR rats compared with vehicle treated SHR rats (P < 0.0001). B. SHR rats exhibited significantly lower extracellular VMH HVA content compared with normal Wistar rats (p < 0.001). C. SHR rats exhibited elevated VMH 5-HIAA release relative to Wistar normal controls (P < 0.0001). Timed daily bromocriptine administration significantly reduced VMH 5-HIAA of SHR rats compared with vehicle treated SHR rats (P < 0.0001) There was no significant difference in VMH 5-HIAA levels between SHR BC treated and Wistar rats.Back to article page