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Table 2 Tissue and conventional Doppler Echocardiographic parameters and grade of left ventricular diastolic dysfunction by tissue Doppler echocardiograms at baseline and after 24 weeks of treatment with sitagliptin in 15 patients (SITA group) or bedtime NPH insulin in 14 patients (NPH group)

From: Left ventricular diastolic function in patients with type 2 diabetes treated with a dipeptidyl peptidase-4 inhibitor- a pilot study

Groups/Patients   Baseline     After 24-wk  
  e’ E/e’ E/A LVDD e’ E/e’ E/A LVDD
SITA 1 7.0 10.1 0.9 II 7.0 2.9 0,5 I
2 7.0 5.1 0.6 I 11.0 4.7 0,6 0
3 8.0 9.5 0.7 0 10.0 5.7 0,6 0
4 7.0 7.6 0.9 I 9.9 9.8 1.1 0
5 6.0 9.7 1.8 II 9.1 8.2 2.0 0
6 7.4 7.2 1.1 I 7.0 6.3 0.8 I
7 8.0 8.1 1.0 0 9.0 10.0 1.0 0
8 8.0 4.3 0.6 0 6.8 5.9 0.6 I
9 10.0 6.3 0.8 0 8.0 8.4 1.5 0
10 15.0 6.0 0.8 0 7.0 10.4 0.7 I
11 7.0 11.1 0.9 II 8.0 8.8 1.0 0
12 10.0 5.6 0.7 0 8.0 8.1 0.8 0
13 4.7 12.1 0.8 II 6.1 6.6 0.5 I
14 10.0 6.1 0.9 0 6.4 7.5 0.7 I
15 7.0 10.0 1.1 I 5.8 12.8 0.9 I
NPH 1 7.0 12.0 0.9 II 7.0 13.3 1.2 II
2 6.0 9.8 0.7 II 5.2 12.0 0.6 II
3 7.0 5.7 0.6 I 7.0 4.7 0.5 I
4 6.0 9.8 0.9 II 10.0 9.2 1.7 0
5 4.0 16.5 0.9 II 5.0 12.4 0.7 II
6 8.0 5.3 0.7 0 9.0 5.3 0.7 0
7 10.0 7.3 1.0 0 10.0 6.0 0.9 0
8 18.0 2.8 0.7 0 8.8 6.6 0.7 0
9 6.1 12.1 0.9 I 7.5 10.0 0.8 II
10 10.0 6.8 0.9 0 6.3 11.4 0.8 II
11 4.6 12.0 0.6 II 6.0 10.8 0.8 II
12 7.1 7.7 0.9 I 7.9 10.0 1.3 I
13 5.0 13.6 0.7 I 4,2 16.2 0.6 I
14 8.0 14.2 1.2 0 9.0 10.0 1.0 0
  1. e’ = early diastolic velocity (cm/s); E/e’ = mitral inflow E velocity to tissue Doppler e’ ratio. E/A = early diastolic to late diastolic velocities ratio; LVDD = left ventricular diastolic dysfunction; 0 = absent LVDD; I = grade I LVDD; II = grade II LVDD; wk = weeks.