Table 1 Clinical and biochemical characteristics of 35 patients with type 2 diabetes at baseline and after 24-wk of sitagliptin or bedtime NPH insulin therapy
SITA | SITA | NPH | NPH | |
|---|---|---|---|---|
Baseline | After 24-wk | Baseline | After 24-wk | |
Number of patients | 18 | 17 | ||
Female/Male | 09/09 | 11/06 | ||
Age (years) | 55.1 ± 6.7 | 58.4 ± 6.9 | ||
Diabetes duration (years) | 10.9 ± 5.8 | 10.9 ± 7.5 | ||
Weight (kg) | 69.4 ± 12.0 | 69.9 ± 11.4 | 73.1 ± 10.1 | 74.0 ± 10.4 |
BMI (kg/m2) | 26.5 ± 2.7 | 26.8 ± 2.6 | 27.5 ± 2.5 | 27.8 ± 2.8 |
Waist-hip ratio | 0.97 ± 0.03 | 0.98 ± 0.05 | 0.96 ± 0.05 | 0.95 ± 0.05 |
sBP vigil (mmHg) | 135.4 ± 14.8 | 130.7 ± 18.9 | 136.2 ± 11.1 | 136.1 ± 10.5 |
dBP vigil (mmHg) | 83.1 ± 7.8 | 81.1 ± 9.6 | 80.3 ± 8.0 | 79.2 ± 6.7 |
sBP sleep (mmHg) | 123.1 ± 14.0 | 122.7 ± 18.8 | 125.2,3 ± 10.7 | 129.2 ± 14.9 |
dBP sleep (mmHg) | 71.6 ± 8.5 | 70.7 ± 9.7 | 70.3 ± 6.8 | 71.3 ± 8.7 |
HbA1c (%) | 8.0 ± 0.6 | 7.3 ± 0.8€ | 8.1 ± 0.7 | 7.3 ± 0.7€ |
Fasting glucose (mg/dL) | 136.5 ± 30.0 | 125.6 ± 33.4 | 159.2 ± 38.0 | 111.6 ± 30.4€ |
Triglycerides (mg/dL) | 139.1 ± 63.5 | 144.1 ± 66.2 | 152.6 ± 80.5 | 130.1 ± 85.3€ |
Total cholesterol (mg/dL) | 171.7 ± 35.1 | 174.7 ± 33.3 | 186.8 ± 29.0 | 185.2 ± 42.0 |
LDL-cholesterol (mg/dL) | 96.6 ± 32.0 | 101.9 ± 26.7 | 114.1 ± 21.0§ | 121.8 ± 25.6£ |
HDL-cholesterol (mg/dL) | 46.2 ± 9.9 | 43.4 ± 8.3 | 42.0 ± 10.2 | 45.5 ± 11.8 |
Active GLP-1 (pmol/L) | 5.0 ± 2.3 | 15.3 ± 10.3€ | 5.0 ± 2.4 | 5.6 ± 2.1& |
C-reactive protein (mg/L) | 2.5 ± 3.1 | 2.1 ± 2.4 | 2.7 ± 2.6 | 2.6 ± 1.6 |