Table 6 Sensitivity analysis based on the daily doses of metformin

Below 1000 mg only

BMI

4

352

0.01

22%

0.28

0.33 [0.09, 0.58]

0.007

SBP

2

177

0.00

0%

0.64

-0.02 [-0.31, 0.28]

0.92

DBP

2

177

0.00

0%

0.67

-0.06 [-0.36, 0.23]

0.69

FPG

5

584

0.02

34%

0.19

0.03 [-0.18, 0.24]

0.77

HbA1c

5

584

0.07

65%

0.02

0.14 [-0.15, 0.44]

0.34

PPBS

3

276

0.04

46%

0.16

0.02 [-0.32, 0.36]

0.91

TC

3

251

0.04

41%

0.18

0.32 [-0.03, 0.66]

0.07

HDL

3

251

0.00

0%

0.83

0.01 [-0.23, 0.26]

0.91

LDL

1

136

NA

NA

NA

0.19 [-0.15, 0.53]

0.27

TG

3

251

0.00

0%

0.67

0.10 [-0.15, 0.34]

0.44

FINS

4

352

0.00

4%

0.37

0.22 [0.00, 0.43]

0.05

1000 mg and above 1000 mg

BMI

6

636

0.87

95%

<0.00001

-0.36 [-1.13, 0.41]

0.36

SBP

3

438

0.17

85%

0.002

0.64 [0.12, 1.16]

0.02

DBP

3

438

0.19

86%

0.0009

0.60 [0.06, 1.14]

0.03

FPG

9

1027

0.04

55%

0.02

-0.05 [-0.24, 0.14]

0.64

HbA1c

8

959

0.00

0%

0.87

-0.08 [-0.21, 0.04]

0.20

PPBS

8

823

0.22

84%

<0.00001

-0.37 [-0.73, -0.01]

0.04

TC

6

636

0.24

85%

<0.00001

0.34 [-0.09, 0.77]

0.12

HDL

6

636

0.39

90%

<0.00001

0.14 [-0.39, 0.68]

0.59

LDL

5

566

0.02

32%

0.21

0.38 [0.17, 0.59]

0.0004

TG

6

636

.0.08

67%

0.010

0.36 [0.07, 0.64]

0.02

FINS

6

667

0.71

95%

<0.00001

-0.02 [-0.72, 0.67]

0.94

Above 1000 mg only

BMI

2

234

0.11

72%

0.06

0.16 [-0.38, 0.69]

0.56

SBP

2

234

0.42

91%

0.001

0.69 [-0.25, 1.63]

0.15

DBP

2

234

0.47

92%

0.0005

0.63 [-0.36, 1.63]

0.21

FPG

3

461

0.07

73%

0.02

0.02 [-0.35, 0.38]

0.93

HbA1c

3

461

0.00

0%

0.91

-0.16 [-0.34, 0.03]

0.10

PPBS

3

461

0.00

0%

0.82

-0.11 [-0.29, 0.07]

0.24

TC

2

234

0.01

17%

0.27

0.23 [-0.07, 0.52]

0.13

HDL

2

234

0.00

0%

0.48

0.06 [-0.20, 0.32]

0.64

LDL

1

164

NA

NA

NA

0.43 [0.12, 0.74]

0.006

TG

2

234

0.04

49%

0.16

0.16 [-0.23, 0.55]

0.42

FINS

4

531

0.71

95%

<0.00001

0.28 [-0.57, 1.13]

0.52