Time course of the blood glucose (Top), serum concentrations of insulin (Second) and C-peptide (Third), molar ratio of C-peptide / insulin (Fourth), and calculated insulin secretion rate (ISR) by deconvolution of serum C-peptide concentration decay curve (Fifth) induced by graded glucose infusion (bottom) in the normal (N), dysmetabolic (DYS) and diabetic (DM) cynomolgus monkeys. Left: Basal level at the resting condition before the graded glucose infusion. Middle: Time course during the graded glucose infusion. Right: Area under the curve (AUC) over the entire 200 min time course. *Significantly different from normal group, # significantly different from dysmetabolic group, p<0.05, by ANOVA with Fisher (LSD) post hoc comparisons.