Table 1 In vitro selectivity of DPP-4 inhibitors (fold selectivity for DPP-4 versus other enzymes) (Adapted from Gupta et al.)[8]
From: Linagliptin: farmacology, efficacy and safety in type 2 diabetes treatment
Idpp4 | FAPα | DPP-8 | DPP-9 |
|---|---|---|---|
Vildagliptin | 285 | 270 | 32 |
Saxagliptin | ? | 390 | 77 |
Sitagliptin | >5.500 | >2.660 | >5.550 |
Alogliptin | >14.000 | >14.000 | >14.000 |
Linagliptin | 89 | 40.000 | >10.000 |