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Table 1 In vitro selectivity of DPP-4 inhibitors (fold selectivity for DPP-4 versus other enzymes) (Adapted from Gupta et al.)[8]

From: Linagliptin: farmacology, efficacy and safety in type 2 diabetes treatment

Idpp4 FAPα DPP-8 DPP-9
Vildagliptin 285 270 32
Saxagliptin ? 390 77
Sitagliptin >5.500 >2.660 >5.550
Alogliptin >14.000 >14.000 >14.000
Linagliptin 89 40.000 >10.000
  1. FAP α Fibroblast activation protein α, DPP-8 Dipeptidyl peptidase-8, DPP-9 Dipeptidyl peptidase-9.