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Table 1 Confirmation (by qRT-PCR) of gene expression changes induced by 24-hour exposure to Pioglitazone at 5.6 mM and 23 mM glucose concentrations

From: Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone

 

Genes

PanChip

qRT-PCR

  

FC

FDR

FC

p-value

5.6 mM

Fabp4

1.6

14.57

5.8

0.02

Insig1

1.4

14.57

2.0

0.02

Scd1

1.5

14.57

1.2

0.32

Scd2

1.4

14.57

1.9

0.03

Sc4mol

1.3

17.95

1.2

0.44

23 mM

Actb

1.4

6.5

1.6

0.17

Bad

1.4

5.0

1.4

0.05

Bax

1.3

4.0

1.5

0.02

Camk2b

1.3

9.3

1.2

0.42

Fabp4

1.4

4.0

5.0

0.02

Hmox1

1.4

7.3

3.4

0.04

ltpr2

1.3

4.0

1.5

0.04

Npy

−1.3

2.3

−2.7

0.19

Prdx6

1.4

11.4

1.3

0.34

 

Sod2

1.4

6.7

4.5

0.02

  1. Positive and negative FC (fold-change) represent, respectively, genes upregulated and downregulated by Pioglitazone. FDR: false-discovery rate.
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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