Table 1 Persons, qualifications and time needed to induce the two diabetes models in the Goettingen minipig and care for the diabetic animals prior to grafting the isolated islets of Langerhans.

diabetes induction with STZ

1 scientist or surgeon

1 animal caretaker

3 hours

diabetes induction with PE

2 surgeons

1 medical assistant

2 anaesthesiologists

6 hours

management of the

STZ diabetes

1 animal caretaker

2 × 30 minutes/day

management of the PE diabetes (early phase)

1 surgeon

Up to 4 hours/day

management of the PE diabetes (late phase)

1 animal caretaker

2 × 30 minutes/day