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Figure 5 | Diabetology & Metabolic Syndrome

Figure 5

From: Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice

Figure 5

Effect of the HF–HS diet on hepatic genes for lipid/cholesterol metabolism and insulin signalling. (A) mRNA expression of genes related to lipid metabolism: LXRa, SREBP1c, SCD-1, FAS, PPARγ, CD36, and LPL. (B) mRNA expression of genes related to cholesterol metabolism: SREBP2, HMGCR, and LDLR. (C) mRNA expression of genes related to insulin signalling: IRS2, Akt2, and AMPK. HF–HS diet: high fat–high sucrose diet. C57BL/6 J mice were fed standard chow diet or the HF–HS diet (milk fat 21% and sucrose 34%) for 2 or 4 weeks. Values are the mean ± SE and are relative to control values, which were set at 1.0. n = 6. * P < 0.05, ** P < 0.01, *** P < 0.001.

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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