Skip to main content

Table 2 Fold increments for inflammatory biomarkers comparing those with metabolic syndrome (n = 984) versus those without the metabolic syndrome (n = 1586)

From: Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study

Biomarker   Model 1   Model 2 - with additional adjustment for the components of the metabolic syndrome
  Sample Size Estimate (95% CI) P-value Sample Size Estimate (95% CI) P-value
C-reactive protein 2555 1.82 (1.67, 1.97) <0.0001 2551 1.07 (0.96, 1.19) 0.23
CD40Ligand 2559 0.89 (0.80, 0.98) 0.02 2555 0.89 (0.77, 1.02) 0.10
Intercellular adhesion molecule-1 2557 1.05 (1.03, 1.07) <0.0001 2553 1.00 (0.97, 1.03) 0.99
Interleukin-6 2553 1.29 (1.22, 1.36) <0.0001 2549 1.02 (0.94, 1.10) 0.67
Monocyte chemoattractant −1 2517 1.03 (1.01, 1.06) 0.01 2513 0.98 (0.95, 1.02) 0.34
Osteoprotegerin 2555 1.00 (0.98, 1.02) 0.92 2551 0.99 (0.96, 1.02) 0.65
P-selectin 2558 1.11 (1.08, 1.15) <0.0001 2554 1.06 (1.02, 1.10) 0.005
Tumor necrosis factor-alpha 1948 1.10 (1.05, 1.15) <0.0001 1945 0.99 (0.93, 1.06) 0.84
Tumor necrosis factor receptor 2 2505 1.09 (1.06, 1.11) <0.0001 2501 1.00 (0.97, 1.03) 0.91
  1. † Adjusted for age, sex, smoking, aspirin use, hormone replacement therapy.
  2. ‡ Adjusted for age, sex, smoking, aspirin use, hormone replacement therapy, lipid lowering medications and hypertension treatment, as well as for the components of the metabolic syndrome: waist circumference, triglycerides level, HDL level, systolic and diastolic blood pressure and anti-hypertensive therapy, and fasting blood glucose.