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Table 2 Measurements of fasting serum lipids, TNF-α, TGF-β, MMP-2, collagen-I, collagen-III and masson trichrome

From: Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs)

Groups
  Control Diabetic Control Diabetic Hypertensive Control Rosiglitazone Rosiglitazone + Felodipine
TGs (mg/dL) 79.50 ± 2.65 95.45 ± 6.38^ 98.95 ± 7.29 75.15 ± 4.94# 75.40 ± 7.31#
T-Chol (mg/dL) 133.38 ± 7.17 194.59 ± 14.36^ 227.76 ± 19.94* 158.90 ± 6.82# 151.98 ± 6.83#a
LDL-C (mg/dL) 72.86 ± 9.39 140.22 ± 14.91^ 175.13 ± 19.69* 104.15 ± 7.64# 96.01 ± 8.08#a
HDL-C (mg/dL) 44.62 ± 3.62 35.28 ± 2.22^ 32.84 ± 1.62* 39.72 ± 2.47# 40.89 ± 2.77#
TNF-α (ng/mL) 203.19 ± 10.88 249.10 ± 13.73^ 274.58 ± 17.38* 217.45 ± 18.23# 211.93 ± 17.91#
TGF-β 1.06 ± 0.09 2.01 ± 0.23^ 2.17 ± 0.29 1.16 ± 0.10# 1.10 ± 0.07#
MMP-2 0.82 ± 0.09 0.06 ± 0.04^ 0.11 ± 0.05* 0.41 ± 0.12# 0.43 ± 0.22#
Collagen-I 0.11 ± 0.04 0.80 ± 0.21^ 1.06 ± 0.27* 0.55 ± 0.09# 0.38 ± 0.11#a
Collagen-III 0.06 ± 0.02 0.11 ± 0.03^ 0.13 ± 0.06 0.06 ± 0.02# 0.06 ± 0.02#
Masson trichrome 13.54 ± 1.31 10.79 ± 1.86^ 22.34 ± 6.29* 8.79 ± 1.44# 10.45 ± 2.96#
Values are expressed as mean ± SD. Number of rats per group n = 10.
  1. STZ, streptozotocin; TGs, triglycerides; T-Chol, total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; TNF-α, tumor necrosis factor alpha; TGF-β, transforming growth factor beta; MMP-2, matrix metalloproteinase-2
  2. ^ Significant difference from normal control at P ≤ 0.05.
  3. * Significant difference from diabetic control at P ≤ 0.05.
  4. # Significant difference from diabetic hypertensive control at P ≤ 0.05.
  5. a Means of treated groups with different superscript are significantly different from each other at P ≤ 0.05.