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Table 5 Comparative efficacy of therapeutic interventions for reducing A1C levels

From: Algorithm for the treatment of type 2 diabetes: a position statement of Brazilian Diabetes Society

Strategy/Drug Expected Reduction in A1C (%)
Weight reduction and increase in physical activity 1.0 - 2.0
Metformin 1.0 - 2.0
Insulin as additional therapy 1.5 - 3.5
Sulfonylurea 1.0 - 2.0
Glitazones 0.5 - 1.4
GLP1 Agonists 0.5 - 1.0
DPP-4 Inhibitors 0.5 - 0.8
Alpha-glycosidase Inhibitors 0.5 - 0.8
Glinides 0.5 - 1.5