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Table 2 Anthropometry, biochemical and inflammatory variables in different moments of the study protocol.

From: Synergistic effect of simvastatin and ezetimibe on lipid and pro-inflammatory profiles in pre-diabetic subjects

  Baseline Monotherapy Combination p value
Ezetimibe group     
Body mass index (kg/m2) 33.0 ± 0.9 32.4 ± 0.9* 32.4 ± 1.0* 0.002
Abdominal circumference (cm) 102.9 ± 2.1 100.6 ± 2.2* 101.4 ± 2.2 0.010
Total cholesterol (mg/dL) 237.4 ± 8.8 197.0 ± 7.2* 147.8 ± 6.4*# <0.001
LDL-cholesterol (mg/dL) 145.9 ± 8.2 112.5 ± 6.4* 66.6 ± 4.8*# <0.001
HDL-cholesterol (mg/dL) 56.1 ± 2.8 55.4 ± 2.1 56.9 ± 2.5 0.855
Triglycerides (mg/dL) 176.8 ± 17.4 145.4 ± 15.9* 121.4 ± 11.3* <0.001
Apolipoprotein B (mg/dL) 115.6 ± 5.0 93.3 ± 4.6* 66.9 ± 3.7*# <0.001
Apolipoprotein A-I (mg/dL) 157.7 ± 5.3 153.2 ± 5.0 151.1 ± 6.3 0.149
Leucocytes (×103 cel/mm3) 5.83 ± 0.26 6.07 ± 0.25 6.00 ± 0.31 0.394
C reactive protein (mg/dL) 0.57 ± 0.12 0.46 ± 0.09 0.44 ± 0.14 0.452
Interleukin-6 (pg/mL) 3.1 ± 0.5 2.5 ± 0.3 2.5 ± 0.2 0.286
TNF-α (pg/mL) 8.8 ± 3.2 5.9 ± 0.3 6.1 ± 0.2 0.229
Simvastatin group     
Body mass index (kg/m2) 31.9 ± 0.7 31.8 ± 0.7 31.6 ± 0.8 0.660
Abdominal circumference (cm) 101.8 ± 1.6 101.8 ± 1.6 101.3 ± 1.9 0.999
Total cholesterol (mg/dL) 214.4 ± 7.9 168.1 ± 8.3* 139.5 ± 7.0*# <0.001
LDL-cholesterol (mg/dL) 129.4 ± 7.4 84.8 ± 7.0* 62.4 ± 5.5*# <0.001
HDL-cholesterol (mg/dL) 53.1 ± 2.3 53.2 ± 2.4 54.5 ± 2.5 0.885
Triglycerides (mg/dL) 160.0 ± 13.1 150.5 ± 17.3 112.6 ± 9.7*# <0.001
Apolipoprotein B (mg/dL) 103.8 ± 4.8 77.9 ± 4.5* 63.3 ± 4.0*# <0.001
Apolipoprotein A-I (mg/dL) 154.9 ± 3.8 152.1 ± 4.2 152.5 ± 4.7 0.375
Leucocytes (×103 cel/mm3) 5.91 ± 0.36 5.87 ± 0.40 5.91 ± 0.44 0.924
C reactive protein (mg/dL) 0.59 ± 0.14 0.48 ± 0.12 0.35 ± 0.12*# 0.023
Interleukin-6 (pg/mL) 2.8 ± 0.3 2.3 ± 0.2 2.5 ± 0.2 0.146
TNF-α (pg/mL) 6.1 ± 0.2 6.2 ± 0.2 6.6 ± 0.4 0.261
  1. Data are expressed in means ± standard error.
  2. * p < 0.017 versus baseline
  3. # p < 0.017 versus monotherapy