Table 1 Characteristics of included studies in Type 1 diabetic pediatrics

Chase [28]

USA

3 months

11

The MiniMed CGM vs. SMBG

18 total sensor days within 30- day (total 6 times) + 4 times SMBG tests

Minimum of 4 daily SMBG tests

• HbA1c

I:5

• Number of hypoglycemic events

C:6

• Number of insulin dosage changes

• Fear of hypoglycemia

Deiss [23]

Germany

3 months

30

The MiniMed CGM vs. SMBG

3 days of CGM every 6 weeks over 12 weeks. (total 2 times) (once open, once blinded) + at least 5 times SMBG tests

At least 5 times per day

• HbA1c

I:15

C:15

Lagarde [24]

USA

6 months

27

RT-CGM vs. SMBG

3 days of CGM (Open) every 2 months. (total 3 times) +Usual practice of monitoring BG

3 days of CGM (Blinded) at 0,2, and 4 months +

• HbA1c

I:18

• AUC for glucose < 70 mg/dL

C:9

Usual practice of monitoring BG

• Duration and severity of hypoglycemia

before meals, at bedtime and at 2:00 hours once weekly.

before meals, at bedtime and at 2:00 hours once weekly.

Yates [25]

Australia

3 months

36

The MiniMed CGMvs.SMBG

3 days of CGM every 3 weeks over 3 months (total 4 times) + at least 4 times SMBG

4 to 6 times daily

• HbA1c

I: 19

• Fructosamine

C:17

JDRF [26]

England

26 weeks

114

CGMS

Use the device on a daily basis + 4times SMBG

At least 4 times daily

• HbA1c

I:56

(DexCom or Medtronic or FreeStyle Navigator) vs. SMBG

• The amount of time in hypoglycemic and hyperglycemic per day

C:58

• relative reduction of 10% or more in the mean glycated hemoglobin level

Bergenstal [14]

England

12 months

156

CGM (Minimed paradigm) Vs. SMBG (Sensor augmented pump vs. MDI)

1-week period/ 6 months + SMBG

Sensor glucose values are collected for 1 week periods at Baseline, 6 months and 1 years (Not Display data)

• HbA1c

I: 78

• Severe rates of hypoglycemia

C: 78

Kondonouri [27]

France

12 months

154

CGM (MiniMed paradigm) vs. SMBG

Use on a daily basis, replace the sensors every 3 days + SMBG (at least 4 times/day)

At least 4 times daily

• HbA1c

I: 76

C: 78

Battelino [15]

Slovenia

6 month

72

CGM (Guardian REAL-Time) vs. SMBG

Used on a daily basis + SMBG

SMBG

• HbA1c

I/C:37

• Changes in glycaemic patterns

C/I:35

• Changes in the time spent in hypoglycemia, hyperglycemia, and euglycaemia

Bukara-Radujkovic [29]

BosniaHerzegovina

6 months

80

CGM (Medtronic Minimed) vs. SMBG

3 days of CGM (only one time) + at least 4 daily SMBG (before and after each main meal, at bedtime and during the night at 2 a.m and 5 a.m)

At least 4 daily SMBG (before and after each main meal, at bedtime and during the night at 2 a.m and 5 a.m)

• HbA1c

I: 40

• Average SMBG values

C: 40

• Numbers of hypo- and hyperglycemic events.

Mauras [30]

USA

26 weeks

137

CGM (FreeStyle Navigator) vs. Usual care

Use CGM on a daily basis (Open) + ≥ 4 times SMBG

Use CGM on a daily basis (Blinded) + ≥ 4 times SMBG

• Decrease in HbA1c of ≥ 0.5% from baseline to 26 weeks with no severe hypoglycemia

I: 69

C: 68