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  1. Research

    Changes of myocardial lipidomics profiling in a rat model of diabetic cardiomyopathy using UPLC/Q-TOF/MS analysis

    Diabetic cardiomyopathy (DCM) is a serious cardiac dysfunction induced by changes in the structure and contractility of the myocardium that are initiated in part by alterations in energy substrates. The underl...

    Shifen Dong, Rong Zhang, Yaoyue Liang, Jiachen Shi, Jiajia Li, Fei Shang, Xuezhou Mao and Jianning Sun

    Diabetology & Metabolic Syndrome 2017 9:56

    Published on: 20 July 2017

  2. Research

    A randomized controlled trial comparing the effects of dapagliflozin and DPP-4 inhibitors on glucose variability and metabolic parameters in patients with type 2 diabetes mellitus on insulin

    Dipeptidyl peptidase-4 (DPP-4) inhibitors and sodium–glucose co-transporter 2 (SGLT2) inhibitors improve hyperglycemia, and the usefulness of co-administration of DPP-4 inhibitors and insulin therapy has been ...

    Hiroshi Nomoto, Hideaki Miyoshi, Hajime Sugawara, Kota Ono, Shingo Yanagiya, Mayuko Oita, Akinobu Nakamura and Tatsuya Atsumi

    Diabetology & Metabolic Syndrome 2017 9:54

    Published on: 17 July 2017

  3. Review

    Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM)

    Since the first position statement on diabetes and cardiovascular prevention published in 2014 by the Brazilian Diabetes Society, the current view on primary and secondary prevention in diabetes has evolved as...

    Marcello Casaccia Bertoluci, Rodrigo Oliveira Moreira, André Faludi, Maria Cristina Izar, Beatriz D. Schaan, Cynthia Melissa Valerio, Marcelo Chiara Bertolami, Ana Paula Chacra, Marcus Vinicius Bolivar Malachias, Sérgio Vencio, José Francisco Kerr Saraiva, Roberto Betti, Luiz Turatti, Francisco Antonio Helfenstein Fonseca, Henrique Tria Bianco, Marta Sulzbach…

    Diabetology & Metabolic Syndrome 2017 9:53

    Published on: 14 July 2017

  4. Short report

    Translation and validation of diabetes self-management profile (DSMP) into Brazilian Portuguese language: first instrument to assess type 1 diabetes self-management in a pediatric population

    To translate and validate the instrument Diabetes Self-Management Profile (DSMP)—Conventional and Flexible Regimens into Brazilian Portuguese language in order to evaluate the quality of diabetes self-manageme...

    Caroline Gouveia Buff Passone, Lygia Spassapan Oliveira Esteves, Roberta Dias Savoldelli, Michael A. Harris, Durval Damiani and Thais Della Manna

    Diabetology & Metabolic Syndrome 2017 9:51

    Published on: 11 July 2017

  5. Research

    Educ@dom: comparative study of the telemonitoring of patients with type 2 diabetes versus standard monitoring—study protocol for a randomized controlled study

    The global prevalence of type 2 diabetes is considerable. To avoid or delay its chronic complications, patients with type 2 diabetes should improve blood glucose management by adapting their life style. This i...

    Marie-Christine Turnin, Solène Schirr-Bonnans, Jacques Martini, Jean-Christophe Buisson, Soumia Taoui, Marie-Christine Chauchard, Nadège Costa, Benoît Lepage, Laurent Molinier and Hélène Hanaire

    Diabetology & Metabolic Syndrome 2017 9:52

    Published on: 11 July 2017

  6. Short report

    Autologous bone marrow-derived mononuclear cells transplantation in type 2 diabetes mellitus: effect on β-cell function and insulin sensitivity

    Insulin resistance and insulin deficiency are the cardinal defects in the pathogenesis of type 2 diabetes mellitus (T2DM). Despite the plethora of anti-diabetic medications, drugs specifically targeting the β-...

    Shobhit Bhansali, Pinaki Dutta, Mukesh Kumar Yadav, Ashish Jain, Sunder Mudaliar, Meredith Hawkins, Anura V. Kurpad, Deepak Pahwa, Ashok Kumar Yadav, Ratti Ram Sharma, Vivekanand Jha, Neelam Marwaha, Shipra Bhansali and Anil Bhansali

    Diabetology & Metabolic Syndrome 2017 9:50

    Published on: 4 July 2017

  7. Research

    Low serum adiponectin level is associated with metabolic syndrome and is an independent marker of peripheral arterial stiffness in hypertensive patients

    Adiponectin has been implicated in metabolic syndrome (MetS) and arterial stiffness (AS). We aim to determine the relationship between serum adiponectin concentration as well as peripheral AS in hypertensive p...

    Ming-Chun Chen, Chung-Jen Lee, Chiu-Fen Yang, Yu-Chih Chen, Ji-Hung Wang and Bang-Gee Hsu

    Diabetology & Metabolic Syndrome 2017 9:49

    Published on: 28 June 2017

  8. Short report

    Metabolic profiling of type 1 diabetes mellitus in children and adolescents: a case–control study

    Type 1 diabetes mellitus (T1DM) is one of the most common pediatric diseases and its incidence is rising in many countries. Recently, it has been shown that metabolites other than glucose play an important rol...

    Liene Bervoets, Guy Massa, Wanda Guedens, Evelyne Louis, Jean-Paul Noben and Peter Adriaensens

    Diabetology & Metabolic Syndrome 2017 9:48

    Published on: 26 June 2017

  9. Research

    Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes

    Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains...

    Thijs T. W. van Herpt, Roosmarijn F. H. Lemmers, Mandy van Hoek, Janneke G. Langendonk, Ronald J. Erdtsieck, Bert Bravenboer, Annelies Lucas, Monique T. Mulder, Harm R. Haak, Aloysius G. Lieverse and Eric J. G. Sijbrands

    Diabetology & Metabolic Syndrome 2017 9:47

    Published on: 19 June 2017

  10. Research

    Understanding the barriers and improving care in type 2 diabetes: Brazilian perspective in time to do more in diabetes

    Type 2 diabetes mellitus (T2DM) is a complex disease, particularly in a continental country like Brazil. We attempted to understand and evaluate the perceptions and routines of Brazilians with T2DM and physici...

    Sérgio Vencio, Päivi M. Paldánius, Matthias Blüher, Daniel Giannella-Neto, Rafael Caiado-Vencio and W. David Strain

    Diabetology & Metabolic Syndrome 2017 9:46

    Published on: 15 June 2017

  11. Research

    Verification of B-lymphocyte activating factor’s involvement in the exacerbation of insulin resistance as well as an autoimmune response in patients with nonalcoholic steatohepatitis and patients with HCV-related chronic liver disease

    Ten to forty percent of nonalcoholic steatohepatitis (NASH) and HCV-related chronic liver disease (CLD-C) patients have antinuclear antibodies (ANAs). However, the relationship between autoimmune response and ...

    Takashi Himoto, Koji Fujita, Takako Nomura, Joji Tani, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba and Tsutomu Masaki

    Diabetology & Metabolic Syndrome 2017 9:45

    Published on: 13 June 2017

  12. Research

    Unacylated ghrelin modulates circulating angiogenic cell number in insulin-resistant states

    Type 2 diabetes (T2D) is associated with reduced numbers and impaired function of circulating angiogenic cells (CAC) which contributes to the progression of atherosclerosis and microvascular disease. Previous ...

    Behiye Özcan, Pieter J. M. Leenen, Patric J. D. Delhanty, Lucy Y. Baldéon-Rojas, Sebastian J. Neggers and Aart Jan van der Lely

    Diabetology & Metabolic Syndrome 2017 9:43

    Published on: 31 May 2017

  13. Research

    Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components

    The metabolic syndrome (MetS) comprises several cardiometabolic risk factors associated with increased risk for both type 2 diabetes and cardiovascular disease. Skin autofluorescence (SAF), a non-invasive biom...

    Robert P. van Waateringe, Sandra N. Slagter, Andre P. van Beek, Melanie M. van der Klauw, Jana V. van Vliet-Ostaptchouk, Reindert Graaff, Andrew D. Paterson, Helen L. Lutgers and Bruce H. R. Wolffenbuttel

    Diabetology & Metabolic Syndrome 2017 9:42

    Published on: 30 May 2017

  14. Research

    Soluble plasma proteins ST2 and CD163 as early biomarkers of nephropathy in Swedish patients with diabetes, 15–34 years of age: a prospective cohort study

    The aim of this study was to investigate plasma levels of sST2 and sCD163 to determine whether they at an early stage could predict development of diabetic nephropathy and/or diabetic retinopathy in patients a...

    My Samuelsson, Jonatan Dereke, Maria K. Svensson, Mona Landin-Olsson and Magnus Hillman

    Diabetology & Metabolic Syndrome 2017 9:41

    Published on: 25 May 2017

  15. Research

    Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease

    The metabolic syndrome (MetS) and its components are well-established risk factors for cardiovascular diseases (CVD). It is inconclusive whether MetS and MetS score are associated with electrocardiographic mar...

    Theodora W. Elffers, Renée de Mutsert, Hildo J. Lamb, Arie C. Maan, Peter W. Macfarlane, Ko Willems van Dijk, Frits R. Rosendaal, J. Wouter Jukema and Stella Trompet

    Diabetology & Metabolic Syndrome 2017 9:40

    Published on: 22 May 2017

  16. Research

    Basal hyperinsulinemia beyond a threshold predicts major adverse cardiac events at 1 year after coronary angiogram in type 2 diabetes mellitus: a retrospective cohort study

    There is a substantial reduction in cardiovascular related morbidity and mortality in the general population attributed to improved treatment of cardiac risk factors and disease, the same magnitude of benefit ...

    Mukund Srinivasan, Padmanabh Kamath, Narayan Bhat, Narasimha Pai, Rajesh Bhat, Tejas Shah, Poornima Manjrekar and Chakrapani Mahabala

    Diabetology & Metabolic Syndrome 2017 9:38

    Published on: 19 May 2017

  17. Research

    Disease management programs for patients with type 2 diabetes mellitus in Germany: a longitudinal population-based descriptive study

    The primary aim of the disease management program (DMP) for patients with diabetes mellitus type 2 is to improve the quality of health care and the treatment process. 12 years after its introduction in Germany...

    Michael Mehring, Ewan Donnachie, Florian Cornelius Bonke, Christoph Werner and Antonius Schneider

    Diabetology & Metabolic Syndrome 2017 9:37

    Published on: 18 May 2017

  18. Research

    Vildagliptin has the same safety profile as a sulfonylurea on bone metabolism and bone mineral density in post-menopausal women with type 2 diabetes: a randomized controlled trial

    Several antidiabetic therapies affect bone metabolism. Sulfonylureas have the lowest impact on bone among oral antidiabetics. The objective of this study is to compare the effects of vildagliptin and gliclazid...

    Andre Gustavo Daher Vianna, Claudio Silva de Lacerda, Luciana Muniz Pechmann, Michelle Garcia Polesel, Emerson Cestari Marino, Victoria Zeghbi Cochenski Borba and Fellype de Carvalho Barreto

    Diabetology & Metabolic Syndrome 2017 9:35

    Published on: 15 May 2017

  19. Review

    Mesenchymal stem cell therapy in type 2 diabetes mellitus

    Type 2 diabetes mellitus (T2DM), which is characterized by the combination of relative insulin deficiency and insulin resistance, cannot be reversed with existing therapeutic strategies. Transplantation of ins...

    Li Zang, Haojie Hao, Jiejie Liu, Yijun Li, Weidong Han and Yiming Mu

    Diabetology & Metabolic Syndrome 2017 9:36

    Published on: 15 May 2017

  20. Research

    Roles of fasting and postprandial blood glucose in the effect of type 2 diabetes on central arterial stiffness: a 5-year prospective community-based analysis

    Cardiovascular disease constitutes a major challenge for the health of community-dwelling population, it is essential to delay the development of atherosclerosis. However, long-term prospective studies analyzi...

    Shihui Fu, Wenji Chen, Leiming Luo and Ping Ye

    Diabetology & Metabolic Syndrome 2017 9:33

    Published on: 12 May 2017

  21. Research

    Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

    Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. Th...

    Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega and Arturo Zarate

    Diabetology & Metabolic Syndrome 2017 9:32

    Published on: 12 May 2017

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