Table 5 Medication group used by patients for control of diabetes mellitus and comorbidities from 2018 to 2022
Medication group | 2018 n = 999 (%) | 2019 n = 999 (%) | 2020 n = 999 (%) | 2021 n = 999 (%) | 2022 n = 999 (%) | Entre 2018 y 2022 n = 999 (%) | p-value |
|---|---|---|---|---|---|---|---|
Hypoglycemic agents | |||||||
Biguanides | 853 (85.8) | 891 (89.5) | 902 (90.7) | 809 (81.0) | 805 (80.6) | 969 (97.0) | < 0.001 |
GLP-1 analogs | 33 (3.3) | 80 (8.0) | 93 (9.3) | 95 (9.5) | 88 (8.8) | 176 (17.6) | < 0.001 |
DPP-4 inhibitors | 572 (57.5) | 660 (66.3) | 673 (67.6) | 602 (60.3) | 614 (61.5) | 876 (87.7) | < 0.001 |
SGLT2 inhibitors | 265 (26.7) | 328 (33.0) | 407 (40.9) | 417 (41.7) | 443 (44.3) | 650 (65.1) | < 0.001 |
Thiazolidinediones | 88 (8.9) | 142 (14.2) | 161 (16.2) | 152 (15.2) | 158 (15.8) | 318 (31.8) | < 0.001 |
Sulfonylureas | 143 (14.4) | 150 (15.1) | 118 (11.9) | 67 (6.7) | 62 (6.2) | 247 (24.7) | < 0.001 |
Insulins | |||||||
Long-acting insulin | 182 (18.3) | 210 (21.1) | 242 (24.2) | 237 (23.7) | 243 (24.3) | 371 (37.1) | < 0.001 |
Ultra-rapid-acting Insulin | 71 (7.1) | 64 (6.4) | 52 (5.2) | 49 (4.9) | 50 (5.0) | 142 (14.2) | 0.065 |
Regular insulin | 72 (7.2) | 64 (6.4) | 52 (5.2) | 33 (3.3) | 30 (3.0) | 100 (10.0) | < 0.001 |
Ultra-long-acting insulin | 0 (0) | 4 (0.4) | 6 (0.6) | 5 (0.5) | 10 (1.0) | 17 (1.7) | 0.010 |
Intermediate-acting Insulin | 6 (0.6) | 9 (0.9) | 6 (0.6) | 1 (0.1) | 0 (0) | 10 (1.0) | 0.017 |
Lipid-lowering medications | |||||||
Statins | 537 (54.0) | 589 (59.2) | 619 (62.2) | 576 (57.7) | 575 (57.6) | 828 (81.9) | < 0.001 |
Fibrates | 147 (14.8) | 134 (13.5) | 130 (13.1) | 118 (11.8) | 123 (12.3) | 273 (27.3) | 0.546 |
Antihypertensive medications | |||||||
Angiotensin II receptor blockers | 275 (27.7) | 319 (32.1) | 352 (35.4) | 328 (32.8) | 342 (34.2) | 504 (50.5) | < 0.001 |
Calcium channel blockers | 96 (9.7) | 121 (12.2) | 135 (13.6) | 143 (14.3) | 152 (15.2) | 227 (22.7) | < 0.001 |
Beta-blockers | 104 (10.5) | 121 (12.2) | 113 (11.4) | 99 (9.9) | 110 (11.0) | 197 (19.7) | 0.271 |
Angiotensin-converting enzyme inhibitor | 142 (14.3) | 148 (14.9) | 119 (12.0) | 87 (8.7) | 80 (8.0) | 242 (24.2) | < 0.001 |
diuretics | 30 (3.0) | 39 (3.9) | 76 (7.6) | 58 (5.8) | 66 (6.6) | 147 (14.7) | < 0.001 |
Antiarrhythmics | 10 (1.0) | 5 (0.5) | 7 (0.7) | 5 (0.5) | 11 (1.1) | 20 (2.0) | 0.206 |
Other medications | |||||||
NSAIDs | 408 (41.0) | 435 (43.7) | 401 (40.3) | 37 (3.7) | 38 (3.8) | 582 (58.3) | < 0.001 |
Gabapentin | 28 (2.8) | 22 (2.2) | 20 (2.0) | 23 (2.3) | 21 (2.1) | 59 (5.9) | 0.80 |
pregabalin | 32 (3.2) | 37 (3.7) | 34 (3.4) | 24 (2.4) | 26 (2.6) | 83 (8.3) | 0.48 |