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Table 2 CGM metrics of the three TIR subgroups in T1D patients

From: Metabolomics analysis of serum and urine in type 1 diabetes patients with different time in range derived from continuous glucose monitoring

Variable

Overall

(N = 85)

TIR-L

(N = 21)

TIR-M

(N = 50)

TIR-H

(N = 14)

P-value

(3 subgroup)

P-value

(TIR-L vs. TIR-H)

TIR (%)

59.50(18.45)

36.50(20.65)

61.95(8.10)

76.50(14.33)

 < 0.001

 < 0.001

TBR (%)

7.50(15.50)

3.10(3.90)

11.30(17.45)

5.60(7.05)

0.001

0.178

TBR1 (%)

4.80(6.15)

2.20(2.65)

7.75(7.85)

4.30(4.23)

 < 0.001

0.019

TBR2 (%)

1.70(7.55)

1.00(1.45)

3.75(9.38)

0.90(2.90)

0.010

0.748

TAR (%)

28.20(30.40)

60.60(21.21)

24.10(18.38)

14.30(14.90)

 < 0.001

 < 0.001

TAR1 (%)

19.60(16.50)

33.60(12.95)

18.75(14.80)

11.75(11.63)

 < 0.001

 < 0.001

TAR2 (%)

5.60(12.20)

29.90(24.20)

4.35(6.45)

0.30(3.63)

 < 0.001

 < 0.001

CV (%)

40.10(10.55)

37.10(13.80)

42.45(10.58)

33.60(6.08)

 < 0.001

0.028

SD (mmol/L)

3.29(0.98)

4.40(1.30)

3.26(0.73)

2.61(0.87)

 < 0.001

 < 0.001

MG (mmol/L)

8.08(2.72)

11.48(2.63)

7.75(2.10)

7.19(1.43)

 < 0.001

 < 0.001

MODD (mmol/L)

3.25(1.22)

4.45(2.00)

3.35(1.01)

2.07(1.09)

 < 0.001

 < 0.001

MAGE (mmol/L)

7.89(2.27)

9.72(3.67)

7.58(1.92)

6.22(2.06)

 < 0.001

 < 0.001

MAG (mmol/L)

1.80(0.41)

2.03(0.63)

1.78(0.45)

1.73(0.34)

 < 0.001

 < 0.001

CONGA

7.53(2.64)

10.58(2.58)

7.12(1.79)

6.49(1.43)

 < 0.001

 < 0.001

LBGI

5.49(5.79)

5.19(4.92)

6.84(5.72)

3.71(2.99)

0.013

0.064

HBGI

8.60(6.19)

20.08(9.05)

8.13(3.57)

5.14(3.48)

 < 0.001

 < 0.001

GRADE

6.02(5.25)

13.47(6.35)

5.89(2.48)

3.69(3.26)

 < 0.001

 < 0.001

JINDEX

41.72(27.70)

89.30(33.98)

39.57(17.58)

30.42(13.99)

 < 0.001

 < 0.001

LI (mmol/L2/h·week−1)

3.93(2.09)

5.43(2.96)

3.92(1.73)

2.99(1.40)

 < 0.001

 < 0.001

MVALUE (mmol/L)

14.54(11.67)

32.37(16.14)

14.28(6.26)

6.62(4.67)

 < 0.001

 < 0.001

  1. Bold text represents P value < 0.05
  2. Median (IQR); Kruskal–Wallis H test; Mann-Whitey U test
  3. CGM, Continuous glucose monitoring; TIR, time in range; TIR-H, high TIR group; TIR-M, moderate TIR group; TIR-L, low TIR group; TBR, time below range; TAR, time above range; CV, coefficient of variation; SD, standard deviation; MG, mean glucose; MODD, mean of daily differences; MAGE, mean amplitude of glycemic excursions; MAG, mean absolute glucose; CONGA, continuous overall net glycemic action; LBGI, low blood glucose index; HBGI, high blood glucose index; GRADE, glycemic risk assessment diabetes equation; LI, lability index
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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