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Table 4 Multivariable adjusted HRs (95% CI) of central adiposity for incident CVD, CV, and total mortality in different glucose tolerance statuses among men, women, and the total population separately

From: The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis

  

NGT

Pre-diabetes

With T2DM

Non-obese

Obese

Non-obese

Obese

Non-obese

Obese

CVD

Women

E/N

401/4870

189/1711

189/1324

135/925

79/311

179/541

HR (95% CI)

Reference

1.51(1.19–1.94)

Reference

0.79(0.57–1.09)

Reference

0.98(0.70–1.39)

p-value

 

0.001

 

0.15

 

0.94

Men

E/N

136/1680

538/3077

64/313

589/2057

18/73

216/551

HR (95% CI)

Reference

1.10(0.89–1.39)

Reference

0.97(0.73–1.30)

Reference

1.10(0.64–1.89)

p-value

 

0.43

 

0.85

 

0.72

Total

E/N

537/6550

727/4788

253/1637

724/2982

97/384

395/1092

HR (95% CI)

Reference

1.27(1.12–1.46)

Reference

1.03(0.87–1.22)

Reference

1.13(0.89–1.43)

p-value

 

 < 0.001

 

0.72

 

0.29

CV mortality

Women

E/N

143/4933

59/1749

81/1365

70/964

39/325

89/591

HR (95% CI)

Reference

1.36(0.98–1.87)

Reference

1.42(1.02–2.00)

Reference

1.05(0.71–1.55)

p-value

 

0.06

 

0.04

 

0.79

Men

E/N

39/1728

193/3247

13/331

235/2233

9/88

131/630

HR (95% CI)

Reference

1.12(0.78–1.62)

Reference

1.67(0.94–2.94)

Reference

1.09(0.55–2.21)

p-value

 

0.54

 

0.08

 

0.79

Total

E/N

182/6661

252/4996

94/1696

305/3197

48/413

220/1221

HR (95% CI)

Reference

1.22(0.96–1.56)

Reference

1.47(1.11–1.95)

Reference

1.08(0.77–1.51)

p-value

 

0.1

 

0.01

 

0.65

All-cause mortality

Women

E/N

649/4933

218/1749

333/1356

217/964

97/325

226/591

HR (95% CI)

Reference

1.24(1.06–1.46)

Reference

1.09(0.91–1.31)

Reference

1.13(0.89–1.44)

p-value

 

0.01

 

0.31

 

0.31

Men

E/N

154/1728

654/3247

71/331

753/2233

26/88

280/630

HR (95% CI)

Reference

1.03(0.85–1.24)

Reference

1.06(0.83–1.37)

Reference

0.77(0.51–1.17)

p-value

 

0.78

 

0.63

 

0.23

Total

E/N

803/6661

872/4996

404/1696

970/3197

123/413

506/1221

HR (95% CI)

Reference

1.13(1.00–1.28)

Reference

1.08(0.93–1.25)

Reference

1.06(0.86–1.31)

p-value

 

0.04

 

0.29

 

0.59

  1. Central adiposity (WC ≥ 95 cm for Iranian men and women; ≥ 88 cm for American men and ≥ 102 cm for American women)
  2. Model adjusted for gender (total population), age, non-HDL-C, current smoking, education levels, hypertension, FHCVD, and prevalent CVD (except for CVD). E number of events, N number of population, HR hazard ratio, CI confidence interval, CVD cardiovascular disease, FHCVD family history CVD, HDL_c high-density lipoprotein cholesterol, BMI body mass index, NGT normal glucose tolerance
  3. Normoglycemia: FPG < 100 mg/dl & no medication; pre-diabetes: FPG 100–126 mg/dl and no medication; type 2 diabetes; FPG ≥ 126 mg/dl or using medication
  4. Significant values are bolded