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Table 3 Multivariable adjusted HRs (95% CI) of general obesity for incident CVD, CV, and total mortality in different glucose tolerance statuses among men, women, and the total population separately

From: The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis

  

NGT

Pre-diabetes

With T2DM

Non-Obese

Obese

Non-Obese

Obese

Non-Obese

Obese

CVD

Women

E/N

424/4895

166/1686

190/1339

134/910

91/363

167/489

HR (95% CI)

Reference

1.24(1.03–1.50)

Reference

1.05(0.83–1.32)

Reference

1.11(0.85–1.46)

p-value

 

0.02

 

0.70

 

0.44

Men

E/N

549/3740

125/1017

474/1696

179/674

126/330

108/294

HR (95% CI)

Reference

1.00(0.81–1.21)

Reference

1.07(0.90–1.27)

Reference

1.32(1.01–1.73)

p-value

 

0.94

 

0.42

 

0.046

Total

E/N

973/8635

291/2703

664/3035

313/1584

217/693

275/783

HR (95% CI)

Reference

1.07(0.93–1.22)

Reference

1.07(0.93–1.23)

Reference

1.19(0.98–1.43)

p-value

 

0.33

 

0.34

 

0.07

CV mortality

Women

E/N

144/4960

58/1722

86/1379

65/950

49/380

79/532

HR (95% CI)

Reference

1.60(1.15–2.20)

Reference

1.27(0.91–1.79)

Reference

0.91(0.62–1.32)

p-value

 

0.005

 

0.16

 

0.62

Men

E/N

174/3918

58/1057

159/1828

89/736

66/374

74/339

HR (95% CI)

Reference

1.41(1.04–1.92)

Reference

1.59(1.23–2.07)

Reference

1.48(1.04–2.12)

p-value

 

0.03

 

 < 0.001

 

0.03

Total

E/N

318/8878

116/2779

245/3207

154/1686

115/754

153/871

HR (95% CI)

Reference

1.81(1.49–2.21)

Reference

1.52(1.23–1.89)

Reference

1.58(1.22–2.04)

p-value

 

 < 0.001

 

 < 0.001

 

 < 0.001

All-cause mortality

Women

E/N

653/4960

214/1722

335/1379

215/950

115/384

208/532

HR (95% CI)

Reference

1.38(1.17–1.63)

Reference

1.14(0.95–1.37)

Reference

1.06(0.84–1.35)

p-value

 

 < 0.001

 

0.15

 

0.60

Men

E/N

652/3918

156/1057

572/1828

252/736

159/379

147/339

HR (95% CI)

Reference

1.12(0.94–1.35)

Reference

1.36(1.17–1.58)

Reference

1.30(1.02–1.65)

p-value

 

0.20

 

 < 0.001

 

0.03

Total

E/N

1305/8878

370/2779

907/3207

467/1686

274/763

355/871

HR (95% CI)

Reference

1.52(1.38–1.68)

Reference

1.38(1.23–1.54)

Reference

1.35(1.14–1.60)

p-value

 

 < 0.001

 

 < 0.001

 

 < 0.001

  1. General obesity (BMI ≥ 30 kg/m2)
  2. Model adjusted for gender (total population), age, non-HDL-C, current smoking, education levels, hypertension, FHCVD, and prevalent CVD (except for CVD). E number of events, N number of population, HR hazard ratio, CI confidence interval, CVD cardiovascular disease, FHCVD family history CVD, HDL_c high-density lipoprotein cholesterol, BMI body mass index, NGT normal glucose tolerance
  3. Normoglycemia: FPG < 100 mg/dl & no medication; pre-diabetes: FPG 100–126 mg/dl and no medication; type 2 diabetes; FPG ≥ 126 mg/dl or using medication
  4. Significant values are bolded