Table 2 Information of genetic instruments
Exposure | Genetic instruments | |
|---|---|---|
Genetic variants associated with eQTL (MAF > 1%; P < 5.0 × 10−8) | Genetic variants associated with LDL-C levels (MAF > 1%; r 2 < 0.30), associated with LDL-C (P < 5.0 × 10−6) | |
HMGCR | 921 common cis-eQTLs top SNP: rs6453133 | 7 common SNPs |
PCSK9 | 24 common cis-eQTLs top SNP: rs472495 | 12 common SNPs |
NPC1L1 | 11 common cis-eQTLs top SNP: rs41279633 | 4 common SNPs |