Table 1 Summary information of lipid-lowering drug categories, targets, and encoding genes
Drug categories | Drug targets | Encoding genes | Gene region(in GRCh37 from Ensembl) |
|---|---|---|---|
HMGCR inhibitors | 3-hydroxy-3-methylglutaryl coenzyme A reductase | HMGCR | Chromosome 5: 74,632,154-74,657,929 |
PCSK9 inhibitors | proprotein convertase subtilisin/kexin type 9 | PCSK9 | Chromosome 1: 55,505,221-55,530,525 |
NPC1L1 inhibitors | Niemann-Pick C1-Like 1 | NPC1L1 | Chromosome 7: 44,552,134-44,580,914 |