Table 3 Participant characteristics Type 2 DM BMI under 25 and over 25
From: Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report
Parameters | BMI < 25 | BMI > 25 | P value |
|---|---|---|---|
n | 9 | 22 | Â |
Sex (male/female) | 4/5 | 11/11 | Â |
Age (years) | 58.6 ± 9.7 | 57.6 ± 12.1 | 0.82 |
Duration of diabetes (years) | 4.0 ± 5.1 | 3.2 ± 4.0 | 0.69 |
BMI (kg/m2) | 22.0 ± 1.6 | 29.2 ± 3.2 | < 0.001 |
Waist circumstance (cm) | 81.3 ± 7.9 | 99.5 ± 8.6 | < 0.001 |
Fasting plasma glucose (mmol/L) | 7.60 ± 1.80 | 6.90 ± 0.70 | 0.23 |
HbA1c (%) | 8.9 ± 1.4 | 7.3 ± 0.8 | < 0.05 |
HbA1c (mmol/mol) | 73 ± 16 | 56 ± 9 |  |
AST (IU/L) | 31.0 ± 25.5 | 34.4 ± 18.4 | 0.73 |
ALT (IU/L) | 39.1 ± 29.8 | 55.0 ± 37.1 | 0.22 |
Gamma-GTP (IU/L) | 44.9 ± 55.3 | 57.9 ± 48.8 | 0.55 |
Fasting insulin (pmol/L) | 38.8 ± 32.0 | 96.4 ± 47.9 | < 0.001 |
Fasting C-peptide (nmol/L) | 0.70 ± 0.30 | 0.90 ± 0.30 | 0.09 |
Postprandial HIC (L·min–1·m2) | 12.8 ± 3.4 | 6.3 ± 1.9 | < 0.001 |
Fasting HIC (L·min–1·m2) | 23.2 ± 12.4 | 10.6 ± 3.7 | < 0.05 |
eGFR (mL/min/1.73 m2) | 90.4 ± 14.8 | 84.0 ± 22.0 | 0.36 |
Creatinine (mg/dL) | 0.60 ± 0.10 | 0.70 ± 0.20 | 0.34 |
HOMA-beta (%) | 31.1 ± 18.7 | 99.9 ± 52.2 | < 0.001 |
HOMA2-beta (%) | 35.4 ± 13.3 | 76.4 ± 30.8 | < 0.001 |
HOMA-IR | 2.5 ± 2.4 | 5.0 ± 2.6 | < 0.05 |
HOMA2-IR | 1.0 ± 0.7 | 1.8 ± 0.9 | < 0.05 |
Sg (min− 1 × 10− 2) | 1.25 ± 0.33 | 1.34 ± 0.26 | 0.44 |
GDR (mg/kg/min) | 6.9 ± 1.7 | 5.7 ± 1.9 | 0.09 |
M/I (100 × mg · kg− 1 · body weight− 1 · min− 1 · mU− 1 · l− 1) | 12.9 ± 9.2 | 5.1 ± 2.8 | < 0.05 |
Whole-body insulin clearance (mL/min) | 2.1 ± 1.4 | 1.4 ± 0.3 | 0.13 |