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Table 2 Correlation between the fasting HIC and clinical parameters

From: Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report

Parameters

T2DM

Non-DM

r-value

P value

r-value

P value

Age (years)

0.27

0.07

-0.19

N.S.

Duration of diabetes (years)

0.05

N.S.

-

 

BMI (kg/m2)

-0.58

< 0.0005

-0.15

N.S.

Waist circumstance (cm)

-0.55

< 0.001

-0.10

N.S.

Fasting plasma glucose (mmol/L)

0.14

0.22

0.05

N.S.

HbA1c (%)

0.49

< 0.05

0.25

0.06

AST (IU/L)

-0.27

0.06

0.18

N.S.

ALT (IU/L)

-0.27

0.08

0.02

N.S.

Gamma-GTP (IU/L)

-0.37

< 0.05

0.05

N.S.

Fasting insulin (pmol/L)

-0.82

< 0.0001

-0.67

< 0.0001

Fasting C-peptide (nmol/L)

-0.42

< 0.01

-0.004

N.S.

eGFR (mL/min/1.73 m2)

-0.08

N.S.

0.13

N.S.

Creatinine (mg/dL)

0.06

N.S.

-0.15

N.S.

HOMA-beta (%)

-0.84

< 0.0001

-0.41

< 0.05

HOMA2-beta (%)

-0.77

< 0.0001

-0.64

< 0.0001

HOMA-IR

-0.77

< 0.0001

-0.62

< 0.0001

HOMA2-IR

-0.80

< 0.0001

-0.57

< 0.0001

Sg (min− 1 × 10− 2)

0.13

N.S.

0.01

N.S

GDR (mg/kg/min)

0.38

< 0.05

0.09

N.S.

M/I ((100 × mg · kg− 1 · body weight− 1 · min− 1 · mU− 1 · l− 1))

0.56

< 0.0005

0.22

N.S.

Whole-body insulin clearance (mL/min)

0.35

< 0.05

-0.01

N.S.

  1. Correlation coefficients were determined using Spearman’s product moment correlation coefficient test. (all n = T2DM 31, Non-DM 39; HOMA2 beta and IR, n = T2DM 28, Non-DM 36)
  2. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; GDR, glucose disposal rate; GGTP, gamma-glutamyl transpeptidase; HbA1c, glycated hemoglobin; HOMA-beta, homeostatic model assessment beta cell function; HOMA-IR, homeostasis model assessment for insulin resistance; N.S., not significant; Sg, glucose effectiveness