Table 1 Participant characteristics
From: Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report
Parameters | T2DM | Non-DM | p-value |
|---|---|---|---|
n | 31 | 39 | Â |
Sex (male/female) | 16/15 | 24/15 | 0.34 |
Age (years) | 57.9 ± 11.3 | 32.3 ± 8.2 | < 0.001 |
Duration of diabetes (years) | 3.8 ± 4.6 | - |  |
BMI (kg/m2) | 27.1 ± 4.3 | 21.8 ± 3.0 | < 0.001 |
Waist circumstance (cm) | 94.1 ± 11.8 | 76.8 ± 10.0 | < 0.001 |
Fasting plasma glucose (mmol/L) | 7.1 ± 1.1 | 4.8 ± 0.4 | < 0.001 |
HbA1c (%) | 7.7 ± 1.4 | 5.3 ± 0.3 | < 0.001 |
HbA1c (mmol/mol) | 60 ± 15 | 34 ± 3 | < 0.001 |
AST (IU/L) | 33.4 ± 20.3 | 21.2 ± 8.9 | < 0.005 |
ALT (IU/L) | 50.4 ± 35.4 | 25.7 ± 24.8 | < 0.005 |
Gamma-GTP (IU/L) | 54.1 ± 50.2 | 23.1 ± 12.1 | < 0.005 |
Fasting insulin (pmol/L) | 80.0 ± 51.0 | 45.7 ± 25.2 | < 0.001 |
Fasting C-peptide (nmol/L) | 0.80 ± 0.30 | 0.49 ± 0.21 | < 0.001 |
Postprandial HIC (L·min–1·m2) | 8.2 ± 3.8 | 6.7 ± 2.1 | 0.06 |
Fasting HIC (L·min–1·m2) | 14.2 ± 9.2 | 12.2 ± 4.7 | 0.23 |
eGFR (mL/min/1.73 m2) | 85.9 ± 20.2 | 97.1 ± 14.0 | < 0.05 |
Creatinine (mg/dL) | 0.70 ± 0.20 | 0.70 ± 0.15 | 0.50 |
HOMA-beta (%) | 80.0 ± 54.8 | 114.3 ± 60.8 | < 0.05 |
HOMA2-beta (%) | 66.2 ± 32.8 | 90.3 ± 28.2 | < 0.05 |
HOMA-IR | 4.2 ± 2.7 | 1.68 ± 1.0 | < 0.001 |
HOMA2-IR | 1.62 ± 0.96 | 0.89 ± 0.46 | < 0.001 |
Sg (min− 1 × 10− 2) | 1.32 ± 0.29 | 2.28 ± 0.78 | < 0.001 |
GDR (mg/kg/min) | 6.0 ± 1.9 | 10.0 ± 2.8 | < 0.001 |
M/I (100 × mg · kg− 1 · body weight− 1 · min− 1 · mU− 1 · l− 1) | 7.3 ± 6.4 | 11.6 ± 5.2 | < 0.005 |
Whole body insulin clearance (mL/min) | 1.6 ± 0.8 | 2.3 ± 4.1 | 0.18 |