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Table 1 Comparison of two groups baseline clinical data and changes in metabolic data recorded after treatment between two groups of newly diagnosed T2DM patients

From: Sodium-dependent glucose transporter 2 inhibitor alleviates renal lipid deposition and improves renal oxygenation levels in newly diagnosed type 2 diabetes mellitus patients: a randomized controlled trial

 

Glimepiride group (n = 31)

Canagliflozin group (n = 33)

P value

Age

47.52 ± 11.72

47.18 ± 11.54

0.909

Sex (M/F)

19/12

17/16

0.431

BMI (kg/m2)

26.12 ± 3.14

26.70 ± 3.06

0.455

Weight (kg)

76.53 ± 15.21

77.52 ± 12.79

0.779

FBG (mmol/L)

8.31 ± 2.11

7.69 ± 1.54

0.187

HbA1C(%)

8.54 ± 1.50

8.14 ± 1.42

0.279

CHO-L (mmol/L)

5.10 ± 1.69

5.13 ± 1.66

0.942

LDL-C (mmol/L)

3.39 ± 0.95

3.32 ± 0.81

0.753

TG (mmol/L)

2.07 ± 1.00

2.16 ± 1.17

0.758

UA (umol/L)

339.70 ± 89.74

340.70 ± 92.13

0.967

Cr (umol/L)

62.87 ± 16.49

60.19 ± 12.63

0.466

BUN (umol/L)

6.76 ± 2.89

5.68 ± 1.59

0.065

ALT (IU/L)

23.51 ± 9.29

24.86 ± 11.37

0.605

AST (IU/L)

23.12 ± 8.72

22.79 ± 10.05

0.891

SBP (mmHg)

125.20 ± 9.28

128.80 ± 15.43

0.263

DBP (mmHg)

79.00 ± 8.79

81.33 ± 11.30

0.362

UACR (mg/g)

10.84 ± 5.87

12.26 ± 4.78

0.292

eGFR (ml/(min.1.73m2))

109.60 ± 17.03

110.90 ± 15.14

0.732

  1. Data are presented as mean ± SD or median (interquartile range) values, p < 0.05
  2. BMI body mass index, FBG fasting blood glucose HbA1c glycosylated haemoglobin CHO-L cholesterol LDL-C low density lipoprotein-cholesterol, TG triglyceride, UA uric acid, Cr Serum creatinine BUN blood urea nitrogen ALT alanine aminotransferase AST aspartate aminotransferase, SBP systolic blood pressure, DBP diastolic blood pressure, UACR urinary albumin-to-creatinine ratio calculated with albumin measured in milligrams and creatinine measured in grams; Estimated glomerular filtration rate(eGFR) calculated according to the CKD-EPI formula