Table 1 The effect of weight loss on obesity-related comorbidities
From: Pharmacotherapy for obesity: moving towards efficacy improvement
Percentage of weight loss | Effect on comorbidities |
|---|---|
 ≥ 2.5% | Prevention of diabetes in impaired blood glucose Improved T2DM |
Decreased plasma levels of triglycerides | |
Improved ovulation and pregnancy in patients with polycystic ovarian syndrome and infertility | |
From 5% to < 10% | Increased HDL |
Improved function and pain of patients with knee osteoarthritis | |
Improved symptoms of urinary incontinence | |
Decreased risk of depression | |
Improved sexual dysfunction | |
Improved quality of life | |
Decreased costs of hospitalization and medications | |
 ≥ 10% | Improved sleep apnea |
Decreased risk of cardiovascular events | |
Improved NASH | |
 ≥ 16% | Reduced risk of mortality |