Table 4 Treatment effect between vildagliptin and control groups in patients with T1DM on AHCL illustrating mean difference (95% confidence interval) of glucometrics and glycemic excursions before and at the end of Ramadan
Variable | Mean difference (95% CI) | p value | |
|---|---|---|---|
Vildagliptin group (n = 23) | Control group (n = 22) | ||
Average SG (mg/dL) | − 12.5 (− 20.955 to − 1.645) | 10.3 (− 1.639 to 22.239) | < 0.001 |
Average SG (mmol/L) | − 0.6 (− 1.124 to − 0.075) | 0.5 (− 0.155 to 1.155) | < 0.001 |
GMI (eA1C %) | − 0.52 (− 0.864 to 0.176) | 0.09 (− 0.405 to 0.585) | < 0.001 |
GMI (eA1C mmol/moL) | − 5.1 (− 8.874 to − 1.326) | 1.2 (− 2.473 to 4.873) | < 0.001 |
CoV (%) | − 5.2 (− 9.937 to − 0.463) | 3.8 (− 1.578 to 9.178) | < 0.001 |
TIR 70–180 mg/dL (3.9–10 mmol/L) (%) | 6.9 (1.797 to 12.003) | 0.2 (− 4.807 to 5.207) | < 0.001 |
TBR < 70 mg/dL (< 3.9 mmol/L) (%) | − 0.3 (− 0.784 to 0.184) | − 0.4 (− 0.915 to 0.115) | 0.161 |
TBR < 54 mg/dL (< 3.0 mmol/L) (%) | 0.0 (− 0.076 to 0.076) | 0.0 (− 0.066 to 0.066) | 1.000 |
TAR 180–250 mg/dL (10.0–13.9 mmol/L) (%) | − 3.9 (− 6.41 to − 1.39) | 0.1 (− 2.346 to 2.546) | < 0.001 |
TAR > 250 mg/dL (> 13.9 mmol/L) (%) | − 2.7 (− 3.336 to − 2.064) | 0.10 (− 0.472 to 0.672) | < 0.001 |
Total daily dose (U/day) | − 6.4 (− 11.714 to − 1.086) | 4.1 (− 1.253 to 9.453) | < 0.001 |
Bolus amount (U/day) | − 4.5 (− 8.064 to − 0.936) | 5.9 (1.333 to 10.467) | < 0.001 |
Auto correction amount (day) | − 1.6 (− 3.372 to − 0.828) | 0.8 (− 0.054 to 1.65) | < 0.001 |
Auto Basal/Basal amount (day) | − 1.9 (− 5.583 to 1.783) | − 1.8 (− 5.931 to 2.331) | 0.857 |
BG at the start of the meal (mg/dL) | − 5.1 (− 24.218 to 14.018) | − 6.3 (− 23.75 to 11.15) | 0.643 |
BG at the start of the meal (mmol/L) | − 0.3 (− 1.356 to 0.756) | − 0.3 (− 1.268 to 0.668) | 1.000 |
BG at 60 min from the start of the meal (mg/dL) | − 19.1 (− 37.486 to − 0.714) | 5.7 (− 14.605 to 26.005) | < 0.001 |
BG at 60 min from the start of the meal (mmol/L) | − 1.1 (− 2.115 to − 0.085) | 0.3 (− 0.809 to 1.409) | < 0.001 |
BG at 120 min from the start of the meal (mg/dL) | − 30.3 (− 57.928 to − 2.672) | − 2.9 (− 22.789 to 16.989) | < 0.001 |
BG at 120 min from the start of the meal (mmol/L) | − 1.7 (− 3.209 to − 0.191) | − 0.2 (− 1.282 to 0.882) | < 0.001 |
BG at 180 min from the start of the meal (mg/dL) | − 34.4 (− 58.527 to − 10.27) | − 11.1 (− 32.418 to 0.218) | < 0.001 |
BG at 180 min from the start of the meal (mmol/L) | − 1.9 (− 3.244 to − 0.556) | − 0.6 (− 1.769 to 0.569) | < 0.001 |
Carbohydrates (g/day) | 55.4 (37.11 to 73.69) | 62.3 (46.53 to 79.06) | 0.194 |
ICR (g) | 1.7 (− 0.021 to 3.421) | − 3.7 (− 5.378 to − 2.022) | < 0.001 |