Table 3 Comparison between vildagliptin and control groups as regards MiniMedâ„¢ 780G glucometrics and glycemic excursions before and at the end of Ramadan among the enrolled patients with T1DM
Variable | Vildagliptin group | p valuea | Control group | p valuea | p valueb | ||
|---|---|---|---|---|---|---|---|
Before Ramadan (n = 25) | End of Ramadan (n = 23) | Before Ramadan (n = 25) | End of Ramadan (n = 22) | ||||
Average SG (mg/dL) | 151.4 ± 20.5 | 140.1 ± 12.5 | 0.025 | 157.9 ± 22.3 | 168.2 ± 19.6 | 0.113 | < 0.001 |
Average SG (mmol/L) | 8.4 ± 1.1 | 7.8 ± 0.7 | 0.032 | 8.8 ± 1.2 | 9.3 ± 1.1 | 0.139 | < 0.001 |
GMI (eA1C %) | 6.94 ± 0.63 | 6.42 ± 0.58 | 0.005 | 6.88 ± 0.55 | 6.97 ± 1.1 | 0.695 | 0.045 |
GMI (eA1C mmol/moL) | 52.2 ± 7.3 | 47.1 ± 5.9 | 0.015 | 51.6 ± 6.8 | 52.8 ± 6.1 | 0.481 | 0.002 |
CoV (%) | 37.0 ± 9.4 | 31.8 ± 7.1 | 0.035 | 37.8 ± 9.1 | 41.6 ± 9.8 | 0.194 | < 0.001 |
TIR 70–180 mg/dL (3.9–10 mmol/L) (%) | 77.8 ± 9.6 | 84.7 ± 8.3 | 0.016 | 78.9 ± 9.1 | 79.1 ± 8.5 | 0.687 | 0.036 |
TBR < 70 mg/dL (< 3.9 mmol/L) (%) | 3.2 ± 0.8 | 2.9 ± 0.9 | 0.212 | 3.5 ± 1.0 | 3.1 ± 0.8 | 0.112 | 0.428 |
TBR < 54 mg/dL (< 3.0 mmol/L) (%) | 0.3 ± 0.14 | 0.3 ± 0.13 | 0.875 | 0.3 ± 0.12 | 0.3 ± 0.11 | 0.971 | 0.986 |
TAR 180–250 mg/dL (10.0–13.9 mmol/L) (%) | 13.6 ± 5.1 | 9.7 ± 3.6 | 0.003 | 13.1 ± 4.2 | 13.2 ± 4.4 | 0.829 | 0.005 |
TAR > 250 mg/dL (> 13.9 mmol/L) (%) | 5.1 ± 1.3 | 2.4 ± 0.9 | < 0.001 | 4.5 ± 1.0 | 4.3 ± 1.1 | 0.479 | < 0.001 |
Total daily dose (U/day) | 49.8 ± 10.2 | 43.4 ± 8.4 | 0.023 | 48.3 ± 8.9 | 52.4 ± 9.9 | 0.164 | 0.002 |
Bolus amount (U/day) | 27.6 ± 6.7 | 23.1 ± 5.8 | 0.015 | 26.7 ± 7.3 | 32.6 ± 8.7 | 0.187 | < 0.001 |
Auto correction amount (day) | 6.7 ± 1.5 | 5.1 ± 1.2 | < 0.001 | 6.3 ± 1.4 | 7.1 ± 1.6 | 0.084 | < 0.001 |
Auto Basal/Basal amount (day) | 22.2 ± 7.8 | 20.3 ± 4.8 | 0.292 | 21.6 ± 6.8 | 19.8 ± 7.7 | 0.397 | 0.689 |
BG at the start of the meal (mg/dL) | 117.1 ± 36.3 | 112.0 ± 30.7 | 0.213 | 120.8 ± 29.2 | 114.5 ± 32.1 | 0.257 | 0.584 |
BG at the start of the meal (mmol/L) | 6.5 ± 2.0 | 6.2 ± 1.7 | 0.512 | 6.7 ± 1.6 | 6.4 ± 1.8 | 0.548 | 0.697 |
BG at 60 min from the start of the meal (mg/dL) | 178.2 ± 37.4 | 159.1 ± 26.3 | 0.041 | 182.6 ± 35.1 | 188.3 ± 36.3 | 0.518 | 0.005 |
BG at 60 min from the start of the meal (mmol/L) | 9.9 ± 2.1 | 8.8 ± 1.4 | 0.036 | 10.1 ± 1.9 | 10.4 ± 2.0 | 0.624 | 0.004 |
BG at 120 min from the start of the meal (mg/dL) | 207.5 ± 51.3 | 177.2 ± 45.7 | 0.033 | 219.3 ± 36.2 | 216.4 ± 33.7 | 0.715 | 0.002 |
BG at 120 min from the start of the meal (mmol/L) | 11.5 ± 2.8 | 9.8 ± 2.5 | 0.032 | 12.2 ± 2.0 | 12.0 ± 1.8 | 0.728 | 0.003 |
BG at 180 min from the start of the meal (mg/dL) | 183.7 ± 46.1 | 149.3 ± 38.4 | 0.005 | 187.8 ± 35.8 | 176.7 ± 39.1 | 0.357 | 0.021 |
BG at 180 min from the start of the meal (mmol/L) | 10.2 ± 2.6 | 8.3 ± 2.1 | 0.006 | 10.4 ± 1.9 | 9.8 ± 2.2 | 0.341 | 0.025 |
Carbohydrates (g/day) | 156.2 ± 28.7 | 211.6 ± 35.3 | < 0.001 | 161.2 ± 25.3 | 226.5 ± 39.2 | < 0.001 | 0.214 |
ICR (g) | 10.2 ± 2.6 | 11.9 ± 3.4 | 0.063 | 10.8 ± 3.0 | 7.1 ± 2.9 | < 0.001 | < 0.001 |
Smart gaurd/week auto mode (%) | 95.5 ± 4.1 | 97.4 ± 5.7 | 0.194 | 96.1 ± 4.4 | 97.7 ± 4.8 | 0.167 | 0.412 |
Sensor wear (%) | 96.8 ± 3.6 | 97.1 ± 4.5 | 0.815 | 95.7 ± 3.9 | 97.8 ± 4.1 | 0.085 | 0.625 |
Exit from AHCL per patient (n/week) | 1.3 ± 0.6 | 1.1 ± 0.4 | 0.186 | 1.2 ± 0.5 | 1.4 ± 0.7 | 0.174 | 0.094 |
BG calibration (n/day) | 3.5 ± 0.6 | 3.8 ± 0.7 | 0.221 | 3.4 ± 0.6 | 3.7 ± 0.6 | 0.125 | 0.616 |
Set change (n of days) | 3.3 ± 1.1 | 3.6 ± 1.0 | 0.307 | 3.4 ± 1.2 | 3.5 ± 1.1 | 0.726 | 0.759 |
Reservoir change (n of days) | 3.4 ± 0.7 | 3.5 ± 0.5 | 0.568 | 3.1 ± 0.5 | 3.3 ± 0.6 | 0.218 | 0.261 |
Number of days fasting completed | – | 27.8 ± 0.5 | – | – | 28.0 ± 0.6 | – | 0.217 |