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Table 2 The effect of amount of physical activity on all-cause mortality and incidence of cardiovascular disease according to the presence of metabolic syndrome

From: Physical activity has a more beneficial effect on the risk of all-cause mortality in patients with metabolic syndrome than in those without

Presence of metabolic syndrome

MET score

N

Events

Person-years

Incidence rate per 1000

Univariate model

Multivariate model 1

Multivariate model 2

Multivariate model 3

All-cause mortality

 MS (−)

Totally sedentary

1709997

67818

14057952.64

4.824

1 (reference)

1 (reference)

1 (reference)

1 (reference)

 1–499

2473546

53916

20456279.16

2.636

0.55 (0.54, 0.55)

0.85 (0.84, 0.86)

0.87 (0.86, 0.88)

0.87 (0.86, 0.88)

 500–999

2068214

51171

17110004.09

2.990

0.62 (0.61, 0.63)

0.81 (0.80, 0.82)

0.84 (0.83, 0.85)

0.84 (0.83, 0.85)

 1000–1499

759903

18762

6297310.76

2.979

0.62 (0.61, 0.63)

0.74 (0.73, 0.75)

0.79 (0.78, 0.80)

0.79 (0.78, 0.80)

 ≥ 1500

362759

13157

2996779.46

4.390

0.91 (0.89, 0.93)

0.76 (0.75, 0.78)

0.82 (0.81, 0.84)

0.83 (0.81, 0.84)

P for trend

     

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 MS ( +)

Totally sedentary

591380

45942

4809944.99

9.551

1 (reference)

1 (reference)

1 (reference)

1 (reference)

 1–499

691591

33941

5672370.44

5.984

0.63 (0.62, 0.64)

0.85 (0.83, 0.86)

0.86 (0.85, 0.87)

0.86 (0.85, 0.87)

 500–999

607456

31689

4981576.91

6.361

0.67 (0.66, 0.68)

0.80 (0.79, 0.81)

0.82 (0.81, 0.83)

0.82 (0.81, 0.83)

 1000–1499

237353

11466

1951561.18

5.875

0.62 (0.60, 0.63)

0.72 (0.71, 0.74)

0.75 (0.74, 0.77)

0.76 (0.74, 0.77)

 ≥ 1500

125910

8108

1030530.11

7.868

0.82 (0.81, 0.84)

0.74 (0.72, 0.76)

0.78 (0.76, 0.80)

0.78 (0.77, 0.80)

P for trend

     

 < 0.001

 < 0.001

 < 0.001

 < 0.001

P for interaction

     

 < 0.001

0.248

 < 0.001

 < 0.001

Incident cardiovascular diseases

 MS (−)

Totally sedentary

1709997

33603

13950759.84

2.409

1 (reference)

1 (reference)

1 (reference)

1 (reference)

 1–499

2473546

29232

20362317.67

1.436

0.60 (0.59, 0.61)

0.84 (0.83, 0.86)

0.87 (0.85, 0.88)

0.89 (0.87, 0.90)

 500–999

2068214

27174

17022721.37

1.596

0.66 (0.65, 0.67)

0.82 (0.80, 0.83)

0.84 (0.83, 0.86)

0.85 (0.81, 0.87)

 1000–1499

759903

10386

6263598.83

1.658

0.69 (0.67, 0.70)

0.78 (0.76, 0.79)

0.82 (0.80, 0.83)

0.83 (0.81, 0.84)

 ≥ 1500

362759

6790

2974979.44

2.282

0.95 (0.92, 0.97)

0.81 (0.79, 0.83)

0.85 (0.83, 0.87)

0.85 (0.83, 0.87)

P for trend

     

 < 0.001

 < 0.001

 < 0.001

 < 0.001

 MS ( +)

Totally sedentary

591380

29762

4712057.42

6.316

1 (reference)

1 (reference)

1 (reference)

1 (reference)

 1–499

691591

24811

5590106.32

4.438

0.70 (0.69, 0.71)

0.90 (0.88, 0.92)

0.91 (0.90, 0.93)

0.89 (0.88, 0.91)

 500–999

607456

22478

4907373.12

4.580

0.73 (0.71, 0.74)

0.84 (0.83, 0.86)

0.87 (0.85, 0.88)

0.86 (0.84, 0.87)

 1000–1499

237353

8280

1923443.14

4.305

0.68 (0.66, 0.70)

0.77 (0.75, 0.79)

0.81 (0.79, 0.83)

0.80 (0.78, 0.82)

 ≥ 1500

125910

5384

1012460.19

5.318

0.84 (0.82, 0.87)

0.77 (0.75, 0.79)

0.81 (0.79, 0.84)

0.82 (0.80, 0.84)

P for trend

     

 < 0.001

 < 0.001

 < 0.001

 < 0.001

P for interaction

     

 < 0.001

 < 0.001

 < 0.001

 < 0.001

  1. Multivariate model 1 was adjusted for age and sex
  2. Multivariate model 2 was adjusted for age, sex, smoking, alcohol consumption, and body mass index
  3. Multivariate model 3 was adjusted for age, sex, smoking, alcohol consumption, income and body mass index
  4. MET metabolic equivalent, MS metabolic syndrome, CI confidence interval
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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