Table 1 Parameters on the whole-body level that were estimated to both the Fast-food study and Topiramate data
From: A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects
Parameter | Description |
|---|---|
lmax | Maximal drug effect |
IC50 | Drug effect at 50% |
h2 | Hill coefficient of drug effect |
h1 | Hill coefficient of energy intake |
dEIss | Change in energy intake at steady state |
thalf | Timepoint where half of \(E{I}_{vehicle}\left(t\right)\) has been reached |
scale | Scaling of insulin resistance effect between human and mouse |