Table 3 Genetic causal effect of potential mediators on HER-positive breast cancer
From: Genetic effect of metformin use on risk of cancers: evidence from Mendelian randomization analysis
Potential mediators | Beta2 | Lo_95CI | Up_95CI | P2_value |
|---|---|---|---|---|
HDL cholesterol | 2.85E−02 |  − 8.63E−02 | 1.43E−01 | 6.27E−01 |
LDL cholesterol | 6.97E−02 |  − 5.83E−02 | 1.98E−01 | 2.86E−01 |
SHBG |  − 8.30E−02 |  − 3.50E−01 | 1.84E−01 | 5.42E−01 |
Total testosterone | 4.06E−01 | 5.62E−02 | 7.56E−01 | 2.29E−02* |
Bioavailable testosterone | 1.73E−01 | 3.61E−02 | 3.81E−01 | 1.05E−01 |
Estradiol levels | 1.34E+00 |  − 6.24E−01 | 3.30E+00 | 1.82E−01 |
Fasting glucose |  − 1.66E−01 |  − 4.72E−01 | 1.39E−01 | 2.86E−01 |