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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: Irisin suppresses pancreatic β cell pyroptosis in T2DM by inhibiting the NLRP3-GSDMD pathway and activating the Nrf2-TrX/TXNIP signaling axis

Fig. 4

Irisin improved islet cell function and insulin resistance in T2DM model mice. (A) H&E staining of the mouse pancreas was performed. (B) Immunofluorescence detection of α and β cell mass was performed, and immunofluorescence images of islets stained with insulin (Ins) (red) and glucagon (Ggc) (green) were captured. (C) α and β cell mass were shown. (D) Fasting plasma glucagon and (E) insulin concentrations in mice were evaluated. (F) Mouse HOMA-IR and (G) HOMA-β values were determined. Scale bar = 50 μm; ***p < 0.001

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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