| Total number of participants | Number of dementia cases | Model 1* | Model 2†| ||
---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |||
CMD status | Â | Â | Â | Â | Â | Â |
 No CMDs | 46 368 | 896 | 1 (ref) |  | 1 (ref) |  |
 1 CMD | 100 640 | 2375 | 1.08 (1.00–1.16) | 0.063 | 1.07 (0.99–1.15) | 0.099 |
  Diabetes | 1360 | 44 | 1.50 (1.11–2.04) | 0.008 | 1.48 (1.09–2.00) | 0.012 |
  CHD | 1996 | 77 | 1.52 (1.20–1.92) | < 0.001 | 1.50 (1.19–1.90) | < 0.001 |
  Stroke | 547 | 25 | 2.05 (1.37–3.04) | < 0.001 | 2.05 (1.38–3.05) | < 0.001 |
  Hypertension | 96 737 | 2229 | 1.05 (0.97–1.14) | 0.19 | 1.05 (0.97–1.13) | 0.26 |
 2 CMDs | 20 918 | 935 | 1.78 (1.62–1.96) | < 0.001 | 1.74 (1.58–1.91) | < 0.001 |
  Diabetes and CHD | 246 | 11 | 1.79 (0.99–3.25) | 0.055 | 1.72 (0.95–3.12) | 0.075 |
  Diabetes and stroke | 40 | 0 |  |  |  |  |
  Diabetes and hypertension | 8638 | 384 | 1.94 (1.72–2.20) | < 0.001 | 1.88 (1.66–2.12) | < 0.001 |
  CHD and stroke | 90 | 12 | 4.40 (2.49–7.79) | < 0.001 | 4.14 (2.34–7.33) | < 0.001 |
  CHD and hypertension | 9590 | 404 | 1.57 (1.40–1.77) | < 0.001 | 1.54 (1.37–1.74) | < 0.001 |
  Stroke and hypertension | 2314 | 124 | 2.08 (1.72–2.51) | < 0.001 | 2.02 (1.68–2.45) | < 0.001 |
 ≥ 3 CMDs | 3612 | 273 | 2.97 (2.58–3.41) | < 0.001 | 2.83 (2.46–3.25) | < 0.001 |
  Diabetes, CHD, and stroke | 15 | 1 | 4.44 (0.63–31.6) | 0.14 | 4.27 (0.60–30.4) | 0.15 |
  Diabetes, CHD, and hypertension | 2333 | 161 | 2.78 (2.35–3.30) | < 0.001 | 2.65 (2.23–3.14) | < 0.001 |
  Diabetes, stroke, and hypertension | 374 | 35 | 3.57 (2.54–5.02) | < 0.001 | 3.44 (2.45–4.83) | < 0.001 |
  CHD, stroke, and hypertension | 673 | 50 | 2.58 (1.94–3.44) | < 0.001 | 2.46 (1.85–3.28) | < 0.001 |
  Diabetes, CHD, stroke, and hypertension | 217 | 26 | 5.84 (3.95–8.63) | < 0.001 | 5.50 (3.72–8.14) | < 0.001 |
Lifestyle category | Â | Â | Â | Â | Â | Â |
 Unfavourable | 25 472 | 898 | 1 (ref) |  | 1 (ref) |  |
 Intermediate | 90 102 | 2387 | 0.75 (0.70–0.81) | < 0.001 | 0.78 (0.72–0.84) | < 0.001 |
 Favourable | 55 964 | 1194 | 0.63 (0.57–0.68) | < 0.001 | 0.67 (0.61–0.73) | < 0.001 |