Fig. 5From: Aerobic exercise and metformin on intermuscular adipose tissue (IMAT): insights from multimodal MRI and histological changes in prediabetic ratsCharacterization of inflammation and immune responses in intermuscular adipose tissues (IMATs). Representative western blots (A, C, E, G, I) and quantification of nuclear factor kappa-B (NF-κB) (B), phosphorylated NF-κB (p-NF-κB; p65) (D), interleukin-6 (IL-6) (J, K), tumor necrosis factor-α (TNF-α) (F) and interleukin-1β (IL-1β) (H). Representative immunostaining and quantification of IL-1β (L, M), TNF-α (N, O), and IL-6 (P, Q) in IMATs. Magnification: ×200; scale bar = 50 μm. CON control, EMA combined therapies + compound-c, EMC combined therapies, EXE moderate exercise, MET metformin; PRE prediabetes. The data shown represent the mean ± standard error of the mean (n = 5–6/group). ap < 0.05 vs. CON group; bp < 0.05 vs.PRE group; cp < 0.05 vs. MET group; dp < 0.05 vs. EXE group; ep < 0.05 vs. EMA group; fp < 0.05 vs. EMC group; p = 0.07 difference between PRE and EMC groups in terms of the phospho-NF-κB: NF-κB ratioBack to article page