Skip to main content

Table 1 Clinical and biological data of the patients studied

From: Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

Parameter

Group 1 (healthy controls)

Group 2 (normoalbuminuria)

Group 3 (microalbuminuria)

Group 4 (macroalbuminuria)

p*

p**

p***

p

Number of subjects

20

28

27

21

–

–

–

–

Age (years)

56.5 (51; 63.5)

60 (56.5; 63.5)

59 (53; 62)

60 (56; 62)

0.50

0.7

0.75

0.74

DM duration (years)

–

8 (7; 10)

8 (5; 13)

11 (8; 12)

0.72

0.01

0.08

0.06

BMI

24.68 (23.84; 29.41)

32.02 (28.74; 34.80)

32.6 (28.08; 38.09)

36.56 (31.05; 40.72)

0.48

0.005

0.08

0.0001

SBP (mmHg)

120 (120; 135)

130 (120; 140)

135 (125; 135)

155 (150; 165)

0.97

<0.0001

<0.0001

0.0001

DBP (mmHg)

70 (60; 80)

75 (70; 80)

75 (70; 80)

90 (85; 95)

0.67

<0.0001

<0.0001

0.0001

Hb (g/dl)

13.8 (13.2; 14.6)

12.95 (12.05; 14.1)

13.4 (12.4; 14)

10.67 (10.33; 11.25)

0.44

<0.0001

<0.0001

0.0001

Serum creatinine (mg/dl)

0.92 (0.83; 0.96)

0.84 (0.76; 1.01)

1.06 (0.98; 1.17)

1.48 (1.34; 1.99)

0.0003

<0.0001

<0.0001

0.0001

eGFR (ml/min/1.73 m2)

99.96 (84.20; 102.28)

94.98 (83.29; 105.84)

66.08 (60.53; 76.08)

39.42 (29.25; 42.57)

0.112

<0.0001

<0.0001

0.0001

Glycaemia (fasting) (mg/dl)

100 (95; 108.5)

149 (116.5; 204)

137 (115; 210)

176 (138; 275)

0.96

0.07

0.06

0.0001

HbA1c (%)

6.2 (5.95; 6.35)

6.75 (6.3; 7.3)

7.17 (6.8; 8.4)

8.68 (7.93; 9.67)

0.008

<0.0001

0.0007

0.0001

Cholesterol (mg/dl)

163 (132.5; 185.5)

215 (194; 246)

238 (191; 288)

274 (244; 343)

0.42

0.0004

0.01

0.0001

Triglycerides (mg/dl)

107.5 (875; 139)

153.5 (109.5; 183.5)

157 (121; 205)

169 (144; 218)

0.63

0.04

0.13

0.0001

hsCRP (mg/dl)

1.2 (0.83; 2.81)

3.95 (2.86; 6.56)

10.25 (9.21; 17.44)

24.2 (19.87; 35.73)

<0.0001

<0.0001

0.0001

0.0001

UACR (mg/g)

17.97 (16.02; 21.36)

27.28 (21.71; 28.26)

79.83 (44.02; 116.29)

908 (527.9; 1267.15)

<0.0001

<0.0001

<0.0001

0.0001

Cystatin C (mg/l)

0.68 (0.59; 0.85)

0.74 (0.66; 0.86)

0.99 (0.95; 1.09)

1.68 (1.49; 2.00)

<0.0001

<0.0001

<0.0001

0.0001

  1. DM: diabetes mellitus; SBP: systolic blood pressure; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate; hsCRP: high-sensitive C-reactive protein; UACR: urinary albumin:creatinine ratio; Clinical and biological data are presented as medians and IQR, as for variables with skewed distribution; podocytes-expressed as mean ± SD; p*: group 2 vs. group 3; p**: group 2 vs. group 4; p***: group 3 vs. group 4; p: group 1 vs. group 2 vs. group 3 vs. group 4
Back to article page

Diabetology & Metabolic Syndrome

ISSN: 1758-5996

Contact us