From: C-peptide is independent associated with diabetic peripheral neuropathy: a community-based study
Non-DPN (128) | P 1V3 | Clinically-DPN (35) | P 1V2 | Comfirmed DPN (57) | P 2V3 | |
---|---|---|---|---|---|---|
Age (year) | 62.3 ± 8.4 | 0.449 | 63.3 ± 10.7 | 0.527 | 64.5 ± 8.8 | 0.726 |
Sex (male %) | 41% | 0.568 | 58.40% | 0.634 | 46% | 0.62 |
Diabetes duration (year) | 8.5 ± 7.2 | 0.084 | 9.7 ± 7.7 | 0.435 | 12.6 ± 6.9 | 0.228 |
Smoking | 12 (9.4%) | 0.736 | 4 (11.4%) | 0.543 | 6 (10.5) % | 0.612 |
BMI (kg/cm2) | 25.1 ± 3.8 | 0.393 | 25.8 ± 4.7 | 0.421 | 26.9 ± 1.3 | 0.167 |
SBP (mmHg) | 133 ± 16 | 0.036 | 135 ± 16 | 0.501 | 141 ± 13 | 0.056 |
DBP (mmHg) | 78 ± 8 | 0.239 | 77 ± 11 | 0.431 | 83 ± 9 | 0.068 |
FPG (mmol/L) | 8.40 ± 2.43 | 0.033 | 8.89 ± 2.33 | 0.523 | 9.37 ± 2.60 | 0.465 |
2 h-PG (mmol/L) | 15.79 ± 4.81 | 0.012 | 16.47 ± 4.63 | 0.607 | 18.14 ± 4.81 | 0.263 |
TC (mmol/L) | 5.30 ± 1.02 | 0.356 | 5.19 ± 1.06 | 0.737 | 5.10 ± 1.26 | 0.823 |
TG (mmol/L) | 2.11 ± 1.17 | 0.742 | 2.38 ± 0.82 | 0.448 | 2.05 ± 1.12 | 0.383 |
HDL-C (mmol/L) | 1.33 ± 0.45 | 0.018 | 1.18 ± 0.18 | 0.217 | 1.14 ± 0.22 | 0.788 |
LDL-C (mmol/L) | 2.96 ± 0.77 | 0.906 | 3.02 ± 0.83 | 0.804 | 2.98 ± 1.09 | 0.878 |
HBA1c (%) | 7.4 ± 1.4 | 0.007 | 7.6 ± 1.4 | 0.929 | 8.5 ± 1.9 | 0.229 |
GA (%) | 18.7 ± 3.7 | 0.091 | 20.4 ± 5.2 | 0.417 | 22.8 ± 6.1 | 0.086 |
Cr (μmol/L) | 61.54 ± 15.35 | 0.276 | 63.94 ± 17.11 | 0.63 | 67.6 ± 17.30 | 0.278 |
eGFR (mL/min/1.73 m2) | 104.35 ± 31.32 | 0.857 | 106.34 ± 26.13 | 0.826 | 105.45 ± 30.86 | 0.93 |
Median MNCV | 53.7 ± 3.1 | <0.001 | 51.2 ± 5.7 | 0.033 | 46.5 ± 3.4 | 0.005 |
Median MNCA | 8.9 ± 2.3 | 0.014 | 7.8 ± 2.8 | 0.398 | 6.9 ± 2.4 | 0.516 |
Median SNCV | 51.8 ± 8.6 | 0.001 | 48.7 ± 8.8 | 0.086 | 41.9 ± 8.3 | 0.028 |
Median SNCA | 21.4 ± 6.8 | <0.001 | 17.0 ± 8.2 | 0.03 | 9.6 ± 5.4 | <0.001 |
Tibial MNCV | 44.5 ± 3.2 | 0.012 | 40.8 ± 5.89 | 0.007 | 35.8 ± 6.0 | 0.15 |
Tibial MNCA | 8.7 ± 3.1 | <0.001 | 8.2 ± 3.7 | 0.649 | 5.2 ± 3.5 | 0.02 |
Sural SNCV | 50.3 ± 8.5 | <0.001 | 47.5 ± 6.3 | 0.114 | 36.3 ± 3.9 | 0.002 |
Sural SNCA | 13.2 ± 5.6 | <0.001 | 10.4 ± 3.2 | 0.114 | 6.1 ± 3.1 | <0.001 |
Insulin | 16 (12.5%) | 0.347 | 7 (20%) | 0.576 | 13 (22.4%) | 0.747 |
Sulfonylureas | 32 (25.0%) | 0.415 | 10 (28.6%) | 0.589 | 21 (36.8%) | 0.467 |
Metformin | 46 (35.9%) | 0.423 | 14 (40%) | 0.71 | 25 (43.8%) | 0.745 |
ACEI or ARB | 33 (25.8%) | 0.768 | 12 (34.3%) | 0.896 | 19 (33.3%) | 0.824 |