Year | 2001 | 2005 | 2010 | 2013 | rs# | p value# |
---|---|---|---|---|---|---|
n | 170 | 170 | 170 | 170 | ||
Sulfonylureas (%) | 78 (46) | 63 (37) | 67 (39) | 59 (35) | 0.02* | |
Glimepiride (n) | 12 | 31 | 54 | 47 | ||
Glimepiridea (mg) | 3 (2, 5.625) [1, 6] | 3 (2, 4) [1, 6] | 1.875 (1, 3) [0.5, 6] | 1 (0.5, 2) [0.5, 6] | −0.45 | <0.01 |
Biguanide (%) | 78 (46) | 83 (49) | 84 (49) | 76 (45) | 0.76* | |
Metformin (n) | 77 | 83 | 84 | 76 | ||
Metformina (mg) | 750 (750, 750) [375, 750] | 750 (750, 750) [250, 750] | 750 (750, 750) [250, 1000] | 750 (750, 1500) [250, 2250] | 0.28 | <0.01 |
Thiazolidine (%) | 5 (3) | 35 (21) | 83 (49) | 48 (28) | <0.01* | |
Pioglitazonea (mg) | 30 (30, 30) [30] | 15 (15, 30) [7.5, 30] | 15 (15, 30) [7.5, 45] | 15 (15, 30) [7.5, 45] | 0.06 | 0.16 |
α-GI (%) | 54 (32) | 56 (33) | 60 (35) | 43 (25) | 0.30* | |
Voglibose (n) | 43 | 50 | 52 | 37 | ||
Voglibosea (mg) | 0.9 (0.6, 0.9) [0.4, 0.9] | 0.6 (0.6, 0.9) [0.2, 0.9] | 0.9 (0.6, 0.9) [0.2, 0.9] | 0.9 (0.6, 0.9) [0.3, 0.9] | 0.26 | <0.01 |
Meglitinides (%) | 12 (7) | 15 (9) | 22 (13) | 8 (5) | 0.44* | |
Nateglinide (n) | 12 | 15 | 19 | 6 | ||
Nateglinidea (mg) | 270 (270, 270) [270, 270] | 270 (270, 270) [60, 270] | 270 (180, 270) [60, 360] | 135 (90, 225) [90, 360] | −0.18 | 0.01 |
DPP4I (%) | 0 (0) | 0 (0) | 1 (1) | 70 (41) | <0.01* | |
Sitagliptin (n) | 0 | 0 | 1 | 52 | ||
Sitagliptina (mg) | 50 (50, 50) [50, 50] | 50 (25, 50) [25, 100] | 0.09 | 0.30 | ||
Insulins (%) | 69 (41) | 96 (57) | 97 (57) | 93 (55) | <0.01* |