Table 1 Summary of anthropometric and biochemical data obtained in the whole study population, in the euthyroid metformin-treated obese diabetic subpopulation (OB-EuM) and the euthyroid obese metformin-untreated subpopulation (Ob-Eu)
From: The impact of the metabolic phenotype on thyroid function in obesity
Variables | Whole population (n = 952) | OB-EuM (n = 306) | Ob-Eu (n = 646) | p |
|---|---|---|---|---|
Males/females | 410/542 | 127/179 | 283/363 | 0.5 |
Age (years) | 56 (49–65) | 58 (50–65) | 55 (48–65) | 0.07 |
BMI (kg/m2) | 44.4 (40.5–48.9) | 45.6 (41.4–49.6) | 43.7 (40.0–48.7) | 0.003 |
Weight (kg) | 117.8 (102.8–133.5) | 118.3 (106.0–134.0) | 117.3 (101.6–133.1) | 0.09 |
Height (cm) | 161.8 (155–171) | 161 (155–170) | 162 (155–171) | 0.3 |
Waist (cm) | 129 (119–138) | 131 (122–140) | 127 (116–137) | <0.001 |
Waist-to-hip ratio | 0.96 (0.89–1.92) | 0.97 (0.91–1.04) | 0.94 (0.88–1.02) | <0.001 |
REE (kcal/day) | 1909 (1651–2247) | 1963 (1740–2280) | 1884 (1598–2233) | 0.003 |
Fat mass (%) | 46.3 (41.0–51.8) | 47.3 (41.9–52.6) | 45.7 (40.4–51.3) | 0.009 |
Body water (%) | 39.7 (36.2–44.2) | 39.5 (36.3–43.9) | 39.8 (36.2–44.4) | 0.7 |
TSH (mIU/L) | 1.72 (1.21–2.47) | 1.72 (1.19–2.45) | 1.72 (1.22–2.47) | 0.7 |
fT4 (nmol/L) | 146.3 (132.5–162.1) | 151.9 (135.1–163.5) | 145.4 (131.3–162.2) | <0.001 |
Insulin (pmol/L) | 100.7 (65.9–145.8) | 98.6 (62.5–150.0) | 102.1 (68.1–143.1) | 0.5 |
Glucose (mmol/L) | 5.77 (5.05–7.21) | 7.38 (6.05–8.99) | 5.38 (5.38–6.22) | <0.001 |
HbA1c (%) | 6.6 (6.0–7.9) | 7.5 (6.5–8.7) | 6.1 (5.7–6.7) | <0.001 |
HOMA-IR | 4.0 (2.5–6.1) | 4.7 (2.9–7.2) | 3.7 (2.3–5.6) | <0.001 |
HOMA-B | 125.2 (72.1–214.1) | 76.3 (42.6–133.1) | 152.0 (97.1–248.3) | <0.001 |
Cholesterol (mmol/L) | 5.10 (4.38–5.80) | 4.79 (4.01–5.44) | 5.26 (4.66–5.98) | <0.001 |
LDL (mmol/L) | 3.12 (2.49–3.76) | 2.75 (2.16–3.39) | 3.30 (2.70–3.93) | <0.001 |
HDL (mmol/L) | 1.09 (0.91–1.35) | 1.04 (0.85–1.27) | 1.11 (0.93–1.37) | <0.001 |
Triglycerides (mmol/L) | 1.59 (1.23–2.18) | 1.73 (1.31–2.37) | 1.55 (1.20–2.09) | <0.001 |
AST (μkat/L) | 0.35 (0.28–0.48) | 0.35 (0.28–0.50) | 0.35 (0.30–0.48) | 0.8 |
ALT (μkat/L) | 0.45 (0.32–0.70) | 0.43 (0.32–0.70) | 0.45 (0.32–0.70) | 0.8 |
γGT (μkat/L) | 0.48 (0.32–0.75) | 0.50 (0.33–0.87) | 0.47 (0.30–0.72) | 0.07 |
ALP (μkat/L) | 1.64 (1.14–3.02) | 1.25 (1.04–1.65) | 2.27 (1.25–3.35) | <0.001 |
CRP (nmol/L) | 5.71 (2.86–10.48) | 5.71 (2.86–11.43) | 5.71 (3.81–10.48) | 0.5 |
Fibrinogen (μmol/L) | 11.64 (10.17–13.38) | 11.44 (9.91–13.17) | 11.76 (10.29–13.52) | 0.04 |