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Table 3 Insulin pharmacokinetic profiles

From: Interactions between kidney disease and diabetes: dangerous liaisons

Insulin type

Onset

Peak

Duration of action

Rapid-acting profile

Regular

30 min

2–4 h

5–7 h

Short-acting profile

Lispro

Aspart

Glulisine

5–15 min

60–90 min

3–4 h

intermediate-acting profile

NPH*

2 h

6–10 h

13–20 h

Long-acting profile

Glargin

~2 h

Flat

20–24 h

Detemir

~2 h

Less-pronounced peak

6–24 h

Ultra-long-acting profile

Degludec

20–40 min

Flat

~42 h