Fig. 3

IRAK-1 mRNA expression is concordant with adipose tissue expression of proinflammatory mediators. The adipose tissue gene expression of IRAK-1 and representative proinflammatory mediators such as TNF-α, IL-6, and IL-18 was determined in 49 non-diabetic and 42 diabetic individuals by using real-time RT-PCR as described in “Patients and methods”. The data show that IRAK-1 gene expression in non-diabetic individuals correlated positively/significantly with a TNF-α (r = 0.46, P = 0.0008); b IL-6 (r = 0.30, P = 0.03); and c IL-18 (r = 0.31, P = 0.028). IRAK-1 gene expression in diabetic patients correlated positively/significantly with d TNF-α (r = 0.32, P = 0.03), while it did not correlate with e IL-6 (r = 0.18, P = 0.24) and f IL-18 (r = 0.17, P = 0.29)