Valvar (n = 20) | P* value | CAD/MS group | |||||
---|---|---|---|---|---|---|---|
Control (n = 17) | Simvastatin (n = 20) | Pioglitazone (n = 18) | Pioglitazone + Simvastatin (n = 18) | P** value | |||
TG (mg/dL) | 103.1 ± 40.48 | 0.002 | 162.88 ± 55.89 | 152 ± 68.64 | 167.89 ± 61.29 | 110.39 ± 22.1 | 0.011 |
LDL-c (mg/dL) | 103.5 ± 29.68 | 0.381 | 123.76 ± 19.13 | 92.45 ± 33.57 | 142 ± 31.15 | 89.06 ± 25.62 | <0.001 |
HDL-c (mg/dL) | 44.1 ± 13.88 | <0.001 | 34.35 ± 3.9 | 40.25 ± 7.5 | 41.39 ± 8.36 | 41.89 ± 6.33 | 0.006 |
Glucose (mg/dL) | 82.95 ± 11.77 | <0.001 | 101.18 ± 12.34 | 93.2 ± 17.11 | 120.44 ± 23.99* | 144.44 ± 31.89* | <0.001 |
HbA1c (%) | 5.63 ± 0.41 | 0.003 | 5.78 ± 0.49 | 5.59 ± 0.57 | 6.72 ± 1.55 | 6.41 ± 1.16 | 0.004 |
Urea (mg/dL) | 17 ± 4.11 | 0.3 | 25 ± 7.5 | 21 ± 3.3 | 31 ± 2.22 | 30 ± 2.24 | 0.011 |
Creatinine (mg/dL) | 0.9 ± 0.2 | 0.42 | 1.1 ± 0.8 | 1.0 ± 0.42 | 1.2 ± 0.9 | 1,25 ± 0.7 | 0.01 |
hsCRP (mg/L) | 3.89 ± 1.49 | 0.466 | 7.42 ± 1.45 | 1.93 ± 1.59 | 2.97 ± 1.21 | 1.88 ± 0.65 | <0.001 |
IL-6 (pg/mL) | 3.51 ± 0.95 | 0.811 | 5.3 ± 1.06 | 3.29 ± 1.15 | 3.15 ± 1.15 | 2.68 ± 0.69 | <0.001 |
TNF-α (pg/mL) | 14.71 ± 4.06 | 0.317 | 16.58 ± 2.4 | 18.28 ± 10.91 | 7.92 ± 1.03 | 8.65 ± 2.1 | <0.001 |
Leptin (pg/mL) | 3519.75 ± 1997.54 | <0.001 | 17043.69 ± 2065.78 | 4836.25 ± 1310.68 | 42899.54 ± 9011.58 | 13979.94 ± 1622.5 | <0.001 |
Resistin (ng/mL) | 4.34 ± 1.09 | <0.001 | 12.1 ± 1.38 | 6.41 ± 0.97 | 5.41 ± 1.32 | 7.41 ± 0.99 | <0.001 |
Adiponectin (mg/mL) | 15280 ± 4389.45 | <0.001 | 1480.59 ± 426.02 | 4601.85 ± 1044.07 | 6099.38 ± 1227.84 | 7427.43 ± 1229.81 | <0.001 |
MCP-1 (pg/mL) | 73 ± 6.23 | <0.001 | 341.93 ± 66.16 | 66.48 ± 11.2 | 381.55 ± 69.28 | 325.98 ± 62.07 | <0.001 |
ADMA (μmol/L) | 0.47 ± 0.13 | 0.595 | 0,53 ± 0.14 | 0.47 ± 0.12 | 0.44 ± 0.33 | 0.34 ± 0.11 | 0.05 |
MMP-9 (ng/mL) | 553.35 ± 157.38 | 0.146 | 577.08 ± 147.01 | 672.65 ± 340.37 | 216.54 ± 32.6 | 362.76 ± 103.57 | <0.001 |