Table 3 List of SNPs selected in the present study
Mechanisms | Gene | NCBI ID | Alteration | Reference | Control | Obtained | HWE |
|---|---|---|---|---|---|---|---|
MAF1(N) | MAF(N) | P-value 2 | |||||
Glucose/insulin homeostasis | CDKAL1 | rs7754840 | C → G | [19] | 0.336 (226) | 0.286 (206) | 0.456 |
CDKN2A/B | rs10811661 | C → T | [19] | 0.199 (226) | 0.201 (206) | 0.056 | |
HHEX | rs1111875 | A → G | [19] | 0.416 (226) | 0.371 (206) | 0.558 | |
IGF2BP2 | rs4402960 | G → T | [19] | 0.280 (118) | 0.272 (206) | 0.422 | |
IL6 | rs1800795 | C → G | [19] | 0.465 (226) | 0.337 (206) | 0.917 | |
KCNJ11 | rs5219 | C → T | [19] | - | 0.333 (206) | 0.532 | |
KCNQ1 | rs2237892 | C → T | [19] | 0.075 (226) | 0.051 (206) | 1.000 | |
MTNR1B | rs10830963 | C → G | [20] | 0.300 (120) | 0.223 (206) | 0.264 | |
PPARG | rs1801282 | C → G | [19] | 0.076 (118) | 0.093 (205) | 1.000 | |
SLC30A8 | rs13266634 | C → T | [19] | 0.239 (226) | 0.286 (206) | 0.761 | |
TCF7L2 | rs7903146 | C → T | [19] | 0.279 (226) | 0.303 (205) | 0.256 | |
ADCY5 | rs11708067 | A → G | [20] | 0.226 (226) | 0.199 (206) | 0.835 | |
KCNQ1 | rs231362 | C → T | [19] | 0.482 (112) | 0.234 (128) | 0.214 | |
Cardiovascular regulation | ACE | rs4646994 | Ins/Del | [21] | - | 0.420 (206) | 0.171 |
NOS1AP | rs12143842 | C → T | [22] | 0.188 (224) | 0.265 (206) | 0.827 | |
ADRB1 | rs1801252 | A → G | [23] | - | 0.108 (206) | 0.711 | |
ADRB2 | rs1042714 | C → G | [24] | 0.467 (120) | 0.407 (204) | 0.898 | |
ADRB2 | rs1042713 | A → G | [24] | 0.358 (226) | 0.362 (206) | 0.903 | |
NOS3 | rs1799983 | G → T | [24] | 0.342 (120) | 0.417 (206) | 0.072 | |
LDLR | rs2228671 | C → T | [25] | 0.106 (226) | 0.124 (206) | 1.000 | |
NOS3 | rs2070744 | C → T | [24] | - | 0.451 (206) | 0.892 | |
Body mass Index | GNPDA2 | rs10938397 | A → G | [26] | 0.446 (112) | 0.481 (206) | 0.309 |
MTCH2 | rs10838738 | A → G | [26] | 0.363 (226) | 0.282 (206) | 0.855 | |
NPC1 | rs1805081 | A → G | [26] | 0.467 (120) | 0.288 (206) | 0.385 | |
PTER | rs10508503 | C → T | [26] | 0.092 (218) | 0.075 (206) | 1.000 | |
SH2B1 | rs7498665 | A → G | [26] | 0.382 (226) | 0.303 (206) | 0.483 | |
FTO | rs9939609 | A → T | [26] | 0.449 (118) | 0.361 (205) | 0.396 | |
ADRB3 | rs4994 | C → T | [27] | 0.088 (226) | 0.090 (205) | 1.000 | |
GABRA2 | rs279871 | A → G | [28] | - | 0.434 (206) | 0.376 | |
NPY | rs16147 | A → G | [29] | 0.491 (226) | 0.450 (206) | 0.222 | |
TMEM18 | rs6548238 | C → T | [26] | 0.150 (220) | 0.127 (205) | 0.542 | |
Lipid/Drug metabolism | APOE | rs7412 | C → T | [25] | - | 0.027 (161) | 1.000 |
CYP2C8 | rs10509681 | C → T | [30] | 0.137 (226) | 0.129 (206) | 0.750 | |
CYP2C9 | rs1799853 | C → T | [30] | 0.104 (106) | 0.138 (206) | 0.750 | |
CYP2D6 | rs16947 | A → G | [31] | - | 0.393 (206) | 0.845 | |
CYP2C19 | rs4244285 | G → A | [32] | 0.155 (116) | 0.129 (206) | 1.000 | |
TPMT | rs1142345 | A → G | [33] | 0.027 (226) | 0.032 (205) | 1.000 |