Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men

Table 3 Univariate correlation analysis of percentage changes of fasting HOMA-IR and OGTT-derived insulin-sensitivity index (Matsuda) with percentage changes of obesity-associated inflammatory markers, adipokines and MRI measured fat index (study subjects: 27 obese non-diabetic men with metabolic syndrome, with weight loss >5%)

Factors (*percentage changes)	HOMA-IR		ISI-Matsuda
Factors (*percentage changes)	Correlation coefficients (r)	p	Correlation coefficients (r)	p
BMI	0.201	0.314	−0.485	0.010
MR measured fat index
waist	−0.014	0.944	−0.434	0.024
Subcutaneous fat area	0.216	0.280	−0.642	<0.001
Abdominal visceral fat area	0.094	0.641	−0.369	0.058
Epicardial adipose tissue thickness
Basal short axis plane
SIVG	0.408	0.035	−0.501	0.008
IIVG	0.259	0.193	−0.359	0.066
RVFW	0.342	0.080	−0.201	0.314
Horizontal long axis plane
RAVG	−0.049	0.808	−0.213	0.287
LAVG	−0.064	0.753	−0191	0.340
AIVG	0.018	0.929	−0.198	0.321
HDL-C	−0.001	0.995	0.195	0.329
Triglyceride	0.037	0.856	−0.234	0.240
MCP-1	−0.164	0.414	0.050	0.803
HsCRP	−0.003	0.989	−0.022	0.911
Adipokines
Adiponectin	0.093	0.643	0.269	0.175
Leptin	0.685	<0.001	−0.439	0.022
PAI	−0.028	0.888	−0.176	0.379

AIVG: anterior interventricular groove; BMI (kg/m²): body mass index = body weight (kg)/height² (m); HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance, defined as glucose mg/dl × insulin μU/mL/405; Hs-CRP: high sensitivity C-reactive protein; IIVG: inferior interventricular groove; LAVG: left atrioventricular groove; MCP-1: monocyte chemotactic protein-1; Oral glucose tolerance test (OGTT)-derived insulin-sensitivity index (ISI), Matsuda: 10,000/sqrt (FBG × FPI × G × I), where FPG is fasting glucose (mM), FPI is fasting insulin (μIU/ml), G is mean glucose (mM), I is mean insulin (μIU/ml) during the OGTT; PAI-1: plasminogen activator protein-1; RAVG: right atrioventricular groove; RVFW: right ventricular free wall; SIVG: superior interventricular groove.
*Percentage of changes = (after - before)/before weight loss.

ISSN: 1758-5996