Figure 1From: Increased SGLT1 expression in salivary gland ductal cells correlates with hyposalivation in diabetic and hypertensive ratsImmunolocalization of the SGLT1 protein in ductal cells of salivary glands. A. SGLT1 protein in ductal cells of submandibular glands of Wistar Kyoto rats (WKY), diabetic WKY (WKY-D), spontaneously hypertensive rats (SHR) and diabetic SHR (SHR-D). A to D: SGLT1 (green), F-actin (red) and nuclear marker (blue). E to H: only SGLT1 in green color. The SGLT1 protein in ductal cells of WKY can be seen in a very low intensity (A and E), whereas the SGLT1 immunoreactivity is clearly observed in WKY-D (B and F) and SHR (C and G); a further increase in SGLT1 can be observed in SHR-D (D and H). Arrowheads and arrows indicate the absence or presence of the SGLT1 protein in the luminal membrane of ductal cells; respectively. Scale bar, 20 μm. Images are representative of 4 animals in each group. B. SGLT1 protein in ductal cells of the parotid glands from Wistar-Kyoto rats that received physiological saline (A, B, E and F) or propranolol (C, D, G and H), and were subjected to 30-min sympathetic stimulation (B, F, D and H) or not (A, E, C and G). A to D: SGLT1 (green), F-actin (red) and nuclear marker (blue); E to H: only SGLT1 in green color. Scale bar, 20 μm. Arrowheads and arrows indicate the absence or presence of the SGLT1 protein in the luminal membrane of ductal cells; respectively. Images are representative of 4 animals in each group.Back to article page